Protein: RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (TFIIH subunit XPB/SSL2) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB/SSL2) (DNA repair helicase RAD25/SSL2) (RNA polymerase II transcription factor B subunit SSL2) (TFB subunit SSL2) (Suppressor of stem-loop mutation 2)

Gene: RAD25, SSL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 49
UniProt ID: Q00578

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000112 - nucleotide-excision repair factor 3 complex
GO:0000439 - transcription factor TFIIH core complex
GO:0001111 - RNA polymerase II promoter clearance
GO:0001113 - transcription open complex formation at RNA polymerase II promoter

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1025779

TFB2
General transcription and DNA repair factor IIH subunit TFB2

5

3

Small-scale

0.925

High

1025780

TFB3
RNA polymerase II transcription factor B subunit 3

5

1

Small-scale

0.915

High

1025783

SSL1
General transcription and DNA repair factor IIH subunit SSL1

3

2

Small-scale

0.834

High

1025788

TFB5
General transcription and DNA repair factor IIH subunit TFB5

4

0

Small-scale

0.833

High

744618

TFB1
General transcription and DNA repair factor IIH subunit TFB1

3

2

Small-scale

0.805

High

449358

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

10

2

Small-scale

0.751

High

1025786

TFB4
General transcription and DNA repair factor IIH subunit TFB4

4

1

Small-scale

0.680

High

1025785

TFB6
General transcription and DNA repair factor IIH subunit TFB6

4

0

Small-scale

0.653

High

393176

HSP82
ATP-dependent molecular chaperone HSP82

2

5

Small-scale

0.619

High

454661

RAD2
DNA repair protein RAD2

2

1

Small-scale

0.619

High

782143

T2EB
Transcription initiation factor IIE subunit beta

2

1

Small-scale

0.619

High

440860

KIN28
Serine/threonine-protein kinase KIN28

2

9

Small-scale

0.595

High

781060

T2EA
Transcription initiation factor IIE subunit alpha

2

2

Small-scale

0.585

High

594512

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

6

Small-scale

0.584

High

707910

TF2B
Transcription initiation factor IIB

2

4

Small-scale

0.584

High

381211

H2B1
Histone H2B.1

1

4

High-throughput

0.575

High

744008

RAD23
UV excision repair protein RAD23

1

7

Small-scale

0.561

High

819514

SSB2
Ribosome-associated molecular chaperone SSB2

2

12

High-throughput

0.552

High

682933

MSH2
DNA mismatch repair protein MSH2

1

0

Small-scale

0.549

High

776633

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.536

High

828309

MKT1
Post-transcriptional regulator MKT1

1

1

High-throughput

0.536

High

788427

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.518

High

926260

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.518

High

665846

KPC1
Protein kinase C-like 1

1

6

High-throughput

0.515

High

826543

MSL1
U2 small nuclear ribonucleoprotein B''

1

13

High-throughput

0.508

High

626852

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

798161

ARPC1
Actin-related protein 2/3 complex subunit 1

1

13

High-throughput

0.494

High

836083

COPB2
Coatomer subunit beta'

1

8

High-throughput

0.494

High

585648

STI1
Heat shock protein STI1

1

8

High-throughput

0.489

High

741061

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

13

High-throughput

0.479

High

750199

UFD4
Ubiquitin fusion degradation protein 4

1

20

Small-scale

0.479

High

790514

CCL1
Cyclin CCL1

1

3

High-throughput

0.479

High

826746

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.479

High

1025781

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

1025782

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

763969

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

394824

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

545916

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

752611

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

781783

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

1025784

IMB1
Importin subunit beta-1

1

2

High-throughput

0.445

High

1025787

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.445

High

645633

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

386825

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

893203

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

550770

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.319

High

599667

STF2
ATPase-stabilizing factor 15 kDa protein

1

0

High-throughput

0.282

High

932197

ALO
D-arabinono-1,4-lactone oxidase

1

0

High-throughput

0.282

High

863693

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025