Protein: PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]

Gene: PUR92, ADE17
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: P38009

Gene Ontology (top 5):
GO:0003937 - IMP cyclohydrolase activity
GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006164 - purine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791981

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

5

3

High-throughput

0.918

High

791958

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

2

3

High-throughput

0.785

High

791974

SOL1
6-phosphogluconolactonase-like protein 1

3

3

High-throughput

0.666

High

791970

SA155
SIT4-associating protein SAP155

2

0

High-throughput

0.587

High

791962

RSP5
E3 ubiquitin-protein ligase RSP5

2

0

Small-scale

0.577

High

743188

PP12
Serine/threonine-protein phosphatase PP1-2

2

1

High-throughput

0.558

High

752156

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.521

High

314864

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.518

High

692500

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.518

High

728700

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.518

High

734075

EF2
Elongation factor 2

1

0

High-throughput

0.518

High

751573

SNC2
Synaptobrevin homolog 2

1

0

High-throughput

0.518

High

788412

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.518

High

791967

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

0

High-throughput

0.518

High

791977

HCH1
Hsp90 co-chaperone HCH1

1

0

High-throughput

0.518

High

791979

SYC
Cysteine--tRNA ligase

1

0

High-throughput

0.518

High

791993

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.518

High

617387

GBB
Guanine nucleotide-binding protein subunit beta

1

0

High-throughput

0.513

High

437913

KAPC
cAMP-dependent protein kinase type 3

1

2

High-throughput

0.501

High

441353

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.501

High

743675

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.494

High

791978

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.494

High

624999

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

560682

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.480

High

791969

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

791973

ENT3
Epsin-3

1

0

Small-scale

0.480

High

392585

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

579231

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

670590

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

789798

SOL2
6-phosphogluconolactonase-like protein 2

1

3

High-throughput

0.479

High

791959

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

791960

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

791976

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

599346

FUS3
Mitogen-activated protein kinase FUS3

1

1

High-throughput

0.457

High

585913

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.457

High

622931

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.457

High

754534

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.457

High

523673

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526456

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544548

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

741400

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

742825

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

791963

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

623839

MYO2
Myosin-2

1

2

Small-scale

0.439

High

732029

MLF3
Protein MLF3

1

0

High-throughput

0.438

High

791961

ATC2
Calcium-transporting ATPase 2

1

0

High-throughput

0.438

High

791972

YJ66
Uncharacterized oxidoreductase YJR096W

1

0

High-throughput

0.438

High

706849

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

737829

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.437

High

791986

TAF7
Transcription initiation factor TFIID subunit 7

1

1

High-throughput

0.437

High

791994

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

675922

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

791990

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.407

High

550757

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.319

High

791982

ALO
D-arabinono-1,4-lactone oxidase

2

0

High-throughput

0.319

High

558681

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.282

High

626564

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.282

High

776555

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.282

High

791985

SKI8
Antiviral protein SKI8

1

0

High-throughput

0.282

High

791987

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.282

High

791996

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.282

High

517998

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

791964

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

791975

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

791988

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

791971

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

791984

RMI1
RecQ-mediated genome instability protein 1

1

0

High-throughput

0.249

Low

791989

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

791991

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

791995

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.249

Low

791968

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.238

Low

791983

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.238

Low

791992

FLC1
Flavin carrier protein 1

1

0

High-throughput

0.238

Low

791965

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

791966

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

791980

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025