Protein: MPS2
Monopolar spindle protein 2

Gene: MPS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P53159

Gene Ontology (top 5):
GO:0000741 - karyogamy
GO:0000781 - chromosome, telomeric region
GO:0005635 - nuclear envelope
GO:0005640 - nuclear outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917801

BBP1
Spindle pole component BBP1

8

0

Small-scale

0.725

High

864785

MPS3
Spindle pole body assembly component MPS3

4

0

Small-scale

0.674

High

824752

MLP2
Protein MLP2

3

1

Small-scale

0.650

High

917786

AF9
Protein AF-9 homolog

4

0

Small-scale

0.649

High

364657

CDK1
Cyclin-dependent kinase 1

3

0

Small-scale

0.641

High

917785

MPS2
Monopolar spindle protein 2

2

0

Small-scale

0.581

High

917799

CSM4
Chromosome segregation in meiosis protein 4

2

0

Small-scale

0.559

High

915406

NBP1
NAP1-binding protein

1

0

Small-scale

0.549

High

623905

MYO2
Myosin-2

1

0

Small-scale

0.529

High

866116

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.518

High

917790

MLP1
Protein MLP1

1

1

Small-scale

0.481

High

755272

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.460

High

779780

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.460

High

813824

MBO1
Gamma tubulin complex adapter SPC72

1

0

Small-scale

0.460

High

829783

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.460

High

914985

NUP84
Nucleoporin NUP84

1

0

Small-scale

0.460

High

917791

VPS20
Vacuolar protein sorting-associated protein 20

1

0

Small-scale

0.460

High

917797

ADY3
Accumulates dyads protein 3

1

0

High-throughput

0.460

High

780971

SPC42
Spindle pole body component SPC42

1

0

Small-scale

0.458

High

806210

SPC97
Spindle pole body component SPC97

1

0

Small-scale

0.458

High

917789

CDC14
Tyrosine-protein phosphatase CDC14

1

0

Small-scale

0.458

High

737418

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.426

High

545642

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

819323

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

917793

SPC24
Kinetochore protein SPC24

7

0

Small-scale

0.391

High

866049

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.310

High

437941

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.261

Low

415235

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.251

Low

438322

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.251

Low

569536

HAP4
Transcriptional activator HAP4

1

0

High-throughput

0.251

Low

639505

RE107
Recombination protein 107

1

0

High-throughput

0.251

Low

646066

KIN3
Serine/threonine-protein kinase KIN3

1

0

High-throughput

0.251

Low

649513

UBA1
Ubiquitin-activating enzyme E1 1

1

0

Small-scale

0.251

Low

649993

SIN3
Transcriptional regulatory protein SIN3

1

0

Small-scale

0.251

Low

737104

CDC11
Cell division control protein 11

1

0

Small-scale

0.251

Low

747745

SMC1
Structural maintenance of chromosomes protein 1

1

0

Small-scale

0.251

Low

749703

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

758123

CASP
Protein CASP

1

0

High-throughput

0.251

Low

776450

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.251

Low

777083

BDF1
Bromodomain-containing factor 1

1

0

High-throughput

0.251

Low

783489

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.251

Low

790336

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

795694

ECM13
Protein ECM13

1

0

High-throughput

0.251

Low

796340

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

797358

ICS2
Increased copper sensitivity protein 2

1

0

High-throughput

0.251

Low

804907

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

809206

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.251

Low

813686

FLO9
Flocculation protein FLO9

1

0

Small-scale

0.251

Low

822460

TBP6
Probable 26S proteasome subunit YTA6

1

0

High-throughput

0.251

Low

824690

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.251

Low

825866

VHR1
Transcription factor VHR1

1

0

High-throughput

0.251

Low

849828

BUD27
Bud site selection protein 27

1

0

High-throughput

0.251

Low

858412

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.251

Low

858512

STB2
Protein STB2

1

0

High-throughput

0.251

Low

864007

SSY5
SPS-sensor serine protease component SSY5

1

0

Small-scale

0.251

Low

917787

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

Small-scale

0.251

Low

917788

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.251

Low

917792

EUC1
Transcription factor-like protein EUC1

1

0

High-throughput

0.251

Low

917794

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

0

High-throughput

0.251

Low

917795

ATG17
Autophagy-related protein 17

1

0

Small-scale

0.251

Low

917796

VAC14
Vacuole morphology and inheritance protein 14

1

0

Small-scale

0.251

Low

917798

RDR1
Protein RDR1

1

0

Small-scale

0.251

Low

917800

GYP5
GTPase-activating protein GYP5

1

0

High-throughput

0.251

Low

917802

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.251

Low

917803

SRN2
Protein SRN2

1

0

High-throughput

0.251

Low

850734

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

575977

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.232

Low

676188

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

694598

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.232

Low

736024

SP110
Spindle pole body component 110

1

0

Small-scale

0.232

Low

797116

CENPL
Inner kinetochore subunit IML3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025