Protein: PHO4
Phosphate system positive regulatory protein PHO4

Gene: PHO4
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P07270

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

454321

PHO2
Regulatory protein PHO2

10

0

Small-scale

0.928

High

454360

PHO4
Phosphate system positive regulatory protein PHO4

5

0

Small-scale

0.855

High

454389

PHO85
Cyclin-dependent protein kinase PHO85

14

1

Small-scale

0.761

High

454395

PHO80
PHO85 cyclin PHO80

6

1

Small-scale

0.733

High

454466

MSN5
Protein MSN5

4

1

Small-scale

0.699

High

454423

IMB3
Importin subunit beta-3

3

0

Small-scale

0.650

High

454476

H3
Histone H3

1

0

High-throughput

0.631

High

454420

TF2B
Transcription initiation factor IIB

3

0

Small-scale

0.619

High

454382

TBP
TATA-box-binding protein

2

0

Small-scale

0.603

High

454401

SIN3
Transcriptional regulatory protein SIN3

2

0

Small-scale

0.592

High

454426

GSP1
GTP-binding nuclear protein GSP1/CNR1

2

0

Small-scale

0.569

High

454427

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

Small-scale

0.561

High

454472

PRS10
26S proteasome subunit RPT4

1

2

Small-scale

0.561

High

454478

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

Small-scale

0.561

High

149489

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.536

High

432442

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.536

High

454366

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.536

High

454376

YG22B
Transposon Ty2-GR2 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454404

STE11
Serine/threonine-protein kinase STE11

1

1

High-throughput

0.536

High

454406

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.536

High

454410

YC21B
Transposon Ty2-C Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454417

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.536

High

454421

XPO1
Exportin-1

1

1

High-throughput

0.536

High

454430

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.536

High

454444

HRB1
Serine/arginine

1

1

High-throughput

0.536

High

454460

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.536

High

454465

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.536

High

454481

YD22B
Transposon Ty2-DR2 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454483

YM13B
Transposon Ty1-MR1 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454486

YM14B
Transposon Ty1-MR2 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454497

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.536

High

454500

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.536

High

454501

NOP56
Nucleolar protein 56

1

1

High-throughput

0.536

High

454502

YD21B
Transposon Ty2-DR1 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454505

RL11B
Large ribosomal subunit protein uL5B

1

1

High-throughput

0.536

High

454507

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

7

High-throughput

0.536

High

454383

INO4
Protein INO4

1

0

Small-scale

0.529

High

454437

BOI1
BEM1-interacting protein 1

1

0

High-throughput

0.518

High

386520

TBB
Tubulin beta chain

1

0

High-throughput

0.513

High

434209

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.513

High

448601

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.513

High

450487

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.513

High

452545

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.513

High

454361

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

High-throughput

0.513

High

454364

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

454379

AK
Aspartokinase

1

0

High-throughput

0.513

High

454397

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.513

High

454398

RCC1
Guanine nucleotide exchange factor SRM1

1

0

High-throughput

0.513

High

454399

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.513

High

454400

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.513

High

454408

STE50
Protein STE50

1

0

High-throughput

0.513

High

454409

NFS1
Cysteine desulfurase, mitochondrial

1

0

High-throughput

0.513

High

454411

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.513

High

454413

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

454414

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.513

High

454418

URA7
CTP synthase 1

1

0

High-throughput

0.513

High

454419

AROC
Chorismate synthase ARO2

1

0

High-throughput

0.513

High

454425

AROG
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

1

0

High-throughput

0.513

High

454433

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.513

High

454443

LSM12
Protein LSM12

1

0

High-throughput

0.513

High

454447

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.513

High

454449

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.513

High

454451

TM108
Protein TMA108

1

0

High-throughput

0.513

High

454456

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.513

High

454458

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.513

High

454461

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.513

High

454464

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.513

High

454480

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.513

High

454485

MYO5
Myosin-5

1

0

High-throughput

0.513

High

454491

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.513

High

454492

CDC73
Cell division control protein 73

1

0

High-throughput

0.513

High

454493

TSR1
Ribosome biogenesis protein TSR1

1

0

High-throughput

0.513

High

454496

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.513

High

454388

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

454393

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.501

High

454412

PCL2
PHO85 cyclin-2

1

1

Small-scale

0.501

High

154109

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.489

High

383052

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.489

High

409655

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.489

High

427639

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.489

High

433348

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.489

High

434113

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.489

High

435485

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.489

High

454362

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.489

High

454363

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.489

High

454367

RS25B
Small ribosomal subunit protein eS25B

1

1

High-throughput

0.489

High

454396

DBP3
ATP-dependent RNA helicase DBP3

1

1

High-throughput

0.489

High

454405

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.489

High

454416

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.489

High

454440

RS27B
Small ribosomal subunit protein eS27B

1

1

High-throughput

0.489

High

454452

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.489

High

454453

RS29A
Small ribosomal subunit protein uS14A

1

1

High-throughput

0.489

High

454454

RS29B
Small ribosomal subunit protein uS14B

1

1

High-throughput

0.489

High

454459

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.489

High

454470

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.489

High

454477

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.489

High

454506

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.489

High

364237

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.481

High

440996

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

454381

SCH9
Serine/threonine-protein kinase SCH9

1

0

High-throughput

0.480

High

454385

CYC8
General transcriptional corepressor CYC8

1

0

Small-scale

0.480

High

454392

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.480

High

454403

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

454432

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.480

High

454438

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.480

High

454468

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

454499

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.480

High

454365

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.479

High

454368

RL11A
Large ribosomal subunit protein uL5A

1

1

High-throughput

0.479

High

454407

PCL1
PHO85 cyclin-1

1

1

Small-scale

0.479

High

454462

ASNS1
Asparagine synthetase [glutamine-hydrolyzing] 1

1

1

High-throughput

0.479

High

454494

YD23B
Transposon Ty2-DR3 Gag-Pol polyprotein

1

7

High-throughput

0.479

High

454390

PHO81
Phosphate system positive regulatory protein PHO81

1

0

Small-scale

0.460

High

403305

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.458

High

448267

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

453866

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

454369

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

454374

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

454384

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.458

High

454424

RME1
Zinc finger protein RME1

1

0

High-throughput

0.458

High

454429

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

454467

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

454473

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

454482

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.458

High

454490

NMA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.458

High

454498

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

454463

ASNS2
Asparagine synthetase [glutamine-hydrolyzing] 2

1

1

High-throughput

0.445

High

454371

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.437

High

454373

RS23B
Small ribosomal subunit protein uS12B

1

1

High-throughput

0.437

High

454503

NOP58
Nucleolar protein 58

1

1

High-throughput

0.437

High

454378

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

454380

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

454402

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

454428

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

454442

PIH1
Protein interacting with Hsp90 1

1

0

High-throughput

0.426

High

454445

STM1
Suppressor protein STM1

1

0

High-throughput

0.426

High

454471

PBP1
PAB1-binding protein 1

1

0

High-throughput

0.426

High

206086

YA075
Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W

1

1

High-throughput

0.407

High

454370

RL43A
Large ribosomal subunit protein eL43A

1

1

High-throughput

0.407

High

454372

RS23A
Small ribosomal subunit protein uS12A

1

1

High-throughput

0.407

High

454479

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

Small-scale

0.292

High

454441

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

0

High-throughput

0.282

High

454386

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.279

Low

454387

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.279

Low

454391

HXKG
Glucokinase-1

1

0

High-throughput

0.279

Low

454394

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.279

Low

454415

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.279

Low

454431

EAP1
Protein EAP1

1

0

High-throughput

0.279

Low

454434

APE3
Aminopeptidase Y

1

0

High-throughput

0.279

Low

454435

GLY1
Low specificity L-threonine aldolase

1

0

High-throughput

0.279

Low

454436

VRP1
Verprolin

1

0

High-throughput

0.279

Low

454439

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.279

Low

454446

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.279

Low

454450

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.279

Low

454455

KRI1
Protein KRI1

1

0

High-throughput

0.279

Low

454457

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.279

Low

454469

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.279

Low

454474

EF3B
Elongation factor 3B

1

0

High-throughput

0.279

Low

454475

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.279

Low

454484

RRB1
Ribosome assembly protein RRB1

1

0

High-throughput

0.279

Low

454487

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.279

Low

454488

BCH1
Protein BCH1

1

0

High-throughput

0.279

Low

454504

GLT1
Glutamate synthase [NADH]

1

0

High-throughput

0.279

Low

361464

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.269

Low

427517

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

454375

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

454377

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

454422

EF2
Elongation factor 2

1

0

High-throughput

0.249

Low

454489

PUR8
Adenylosuccinate lyase

1

0

Small-scale

0.249

Low

454495

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

454448

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025