HitPredict

Interactor 1: TNIK (P83510)
Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Interactor 2: SYNE1 (Q6ZWR6)
Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)
Gene: SYNE1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1323 Mm			1 8799
+	Hs
		1338588 TNIK_HUMAN (1-1323): 0: 1231: 95.29		SYNE1_HUMAN (1-8799): 0: 1951: 84.71
+	Mm
		1013626 TNIK_MOUSE (1-1323): 0: 1263: 100.00		SYNE2_MOUSE (13-6699): 3.84e-137: 490: 12.49
+	Hs
		1360693 TNIK_HUMAN (1-1323): 0: 1231: 95.29		SYNE2_HUMAN (5-6689): 1.4e-144: 515: 11.64
+	Mm
		597648 TNIK_MOUSE (1-1323): 0: 1263: 100.00		SPTN1_MOUSE (7215-8748): 1.39e-54: 217: 12.84
+	Hs
		1461052 TNIK_HUMAN (1-1323): 0: 1231: 95.29		MACF1_HUMAN (15-1464): 1.99e-63: 246: 14.80
+	Mm
		1013714 TNIK_MOUSE (1-1323): 0: 1263: 100.00		MACF1_MOUSE (6110-8768): 7.22e-51: 205: 11.96
+	Mm
		1013689 TNIK_MOUSE (1-1323): 0: 1263: 100.00		DYST_MOUSE (6614-8775): 2.09e-46: 190: 10.71
+	Mm
		1013598 TNIK_MOUSE (1-1323): 0: 1263: 100.00		SPTB2_MOUSE (7553-8762): 1.63e-25: 120: 11.18
+	Mm
		86342 TNIK_MOUSE (1-1323): 0: 1263: 100.00		B9EKJ1_MOUSE (786-1891): 8.25e-20: 102: 13.42
+	Hs
		1028907 TNIK_HUMAN (1-1323): 0: 1231: 95.29		SPTB2_HUMAN (7553-8762): 3.72e-26: 123: 11.42
+	Mm
		1013604 TNIK_MOUSE (1-1323): 0: 1263: 100.00		Q68FG2_MOUSE (5572-7404): 4.07e-14: 83.1: 9.34
+	Hs
		1040399 TNIK_HUMAN (1-1323): 0: 1231: 95.29		DYST_HUMAN (184-1618): 1.84e-19: 101: 11.04
+	Hs
		692161 MARK3_HUMAN (3-717): 3.48e-125: 407: 16.08		MACF1_HUMAN (15-1464): 1.99e-63: 246: 14.80
+	Mm
		267277 CSKP_MOUSE (22-704): 3.43e-124: 410: 15.75		DYST_MOUSE (6614-8775): 2.09e-46: 190: 10.71
+	Hs
		1093102 STK4_HUMAN (5-470): 4.38e-119: 381: 32.59		SPTN1_HUMAN (7215-8748): 7.87e-55: 217: 12.97
+	Hs
		862669 MARK2_HUMAN (8-709): 3.78e-130: 422: 17.94		UTRN_HUMAN (7098-8758): 5.11e-26: 122: 12.15
+	Hs
		168651 CSKP_HUMAN (22-702): 4.13e-125: 412: 15.80		UTRN_HUMAN (7098-8758): 5.11e-26: 122: 12.15
+	Hs
		692010 MARK3_HUMAN (3-717): 3.48e-125: 407: 16.08		UTRN_HUMAN (7098-8758): 5.11e-26: 122: 12.15
+	Hs
		547463 MARK2_HUMAN (8-709): 3.78e-130: 422: 17.94		DMD_HUMAN (7740-8771): 5.47e-15: 86.1: 11.83
+	Hs
		168623 CSKP_HUMAN (22-702): 4.13e-125: 412: 15.80		DMD_HUMAN (7740-8771): 5.47e-15: 86.1: 11.83