HitPredict

Interactor 1: TRA2A (Q13595)
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)
Gene: TRA2A

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0048026 - positive regulation of mRNA splicing, via spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 282
+	Hs
		925007 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		925116 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		516744 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1020251 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		1031314 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516502 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		925150 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Zm
		9810 A0A1D6EZQ5_MAIZE (6-277): 7.27e-46: 162: 15.07		B4F8E1_MAIZE (10-173): 5.68e-19: 84.6: 31.93
+	Hs
		1020249 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516484 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516339 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516495 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516689 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		PABP3_HUMAN (2-103): 2.88e-19: 89.4: 19.61
+	Hs
		516471 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		TIAR_HUMAN (8-102): 5.22e-19: 87.5: 26.32
+	Hs
		925019 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Mm
		665745 PABP1_MOUSE (1-267): 1.23e-37: 142: 13.77		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		516451 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Mm
		857303 TRA2B_MOUSE (1-279): 2.66e-34: 127: 52.30		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89