HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 238
+	Hs
		834087 CLK3_HUMAN (1-638): 0: 542: 100.00		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		432605 CLK3_HUMAN (1-638): 0: 542: 100.00		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		834022 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		834026 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		833742 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		833788 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		625466 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		833887 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		833938 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		833711 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		432550 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		432604 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		833865 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		833720 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		833870 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		625590 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33