HitPredict

Interactor 1: FLT3 (Q00342)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135)
Gene: FLT3

Interactor 2: SOCS6 (Q9JLY0)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.80	0.609

Property	Details
Experiments	22952242
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1000 Mm			1 533
+	Hs
		156011 FLT3_HUMAN (1-995): 0: 773: 82.87		SOCS6_HUMAN (1-533): 0: 634: 84.39
+	Mm
		431462 KIT_MOUSE (65-990): 0: 613: 30.11		SOCS6_MOUSE (1-533): 0: 658: 100.00
+	Hs
		473374 FLT3_HUMAN (1-995): 0: 773: 82.87		HCK_HUMAN (234-493): 8.77e-59: 205: 15.30
+	Mm
		205445 FLT3_MOUSE (1-1000): 0: 788: 98.51		SOCS2_MOUSE (337-533): 3.99e-53: 180: 29.56
+	Hs
		440418 FLT3_HUMAN (1-995): 0: 773: 82.87		FYN_HUMAN (258-504): 7.97e-55: 195: 14.06
+	Hs
		557144 FLT3_HUMAN (1-995): 0: 773: 82.87		SRC_HUMAN (256-493): 1.52e-54: 194: 14.92
+	Hs
		463008 FLT3_HUMAN (1-995): 0: 773: 82.87		YES_HUMAN (318-493): 3.17e-53: 190: 15.14
+	Hs
		439973 FLT3_HUMAN (1-995): 0: 773: 82.87		LCK_HUMAN (260-493): 9.98e-53: 188: 17.21
+	Hs
		486663 FLT3_HUMAN (1-995): 0: 773: 82.87		FGR_HUMAN (255-493): 2.07e-50: 182: 15.60
+	Hs
		463381 FLT3_HUMAN (1-995): 0: 773: 82.87		LYN_HUMAN (279-493): 2.86e-50: 181: 16.60
+	Hs
		786988 FLT3_HUMAN (1-995): 0: 773: 82.87		BLK_HUMAN (303-493): 1.68e-47: 174: 17.84
+	Hs
		787012 FLT3_HUMAN (1-995): 0: 773: 82.87		SLAP1_HUMAN (300-529): 2.42e-46: 165: 16.19
+	Hs
		155086 FLT3_HUMAN (1-995): 0: 773: 82.87		SOCS2_HUMAN (342-533): 1.29e-44: 158: 30.81
+	Hs
		193221 FLT3_HUMAN (1-995): 0: 773: 82.87		SOCS1_HUMAN (377-533): 1.33e-41: 150: 26.75
+	Hs
		699618 FLT3_HUMAN (1-995): 0: 773: 82.87		P85A_HUMAN (382-494): 6.55e-13: 73.6: 23.89
+	Hs
		155068 KIT_HUMAN (33-990): 0: 606: 28.81		SOCS2_HUMAN (342-533): 1.29e-44: 158: 30.81
+	Mm
		205417 KIT_MOUSE (65-990): 0: 613: 30.11		SOCS1_MOUSE (377-533): 4.62e-41: 148: 26.75
+	Mm
		148471 KIT_MOUSE (65-990): 0: 613: 30.11		P85B_MOUSE (378-489): 1.36e-14: 78.6: 27.68
+	Mm
		431450 KIT_MOUSE (65-990): 0: 613: 30.11		P85A_MOUSE (382-494): 7.21e-13: 73.2: 23.89
+	Hs
		136269 KIT_HUMAN (33-990): 0: 606: 28.81		P85B_HUMAN (378-489): 1.33e-14: 78.6: 27.68