HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: CCNI (Q14094)
Cyclin-I
Gene: CCNI

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	32296183, 33961781, 25852190, 36736316, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 377
+	Hs
		667839 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNI_HUMAN (1-377): 6.51e-115: 340: 100.00
+	Hs
		1025264 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		CCNI_HUMAN (1-377): 6.51e-115: 340: 100.00
+	Hs
		667764 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNA1_HUMAN (9-275): 1.53e-84: 266: 15.67
+	Hs
		573751 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNB1_HUMAN (5-272): 1.51e-81: 257: 18.52
+	Hs
		573801 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		CCNB1_HUMAN (5-272): 1.51e-81: 257: 18.52
+	Hs
		573802 CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00		CCNB1_HUMAN (5-272): 1.51e-81: 257: 18.52
+	Hs
		325466 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNB2_HUMAN (5-287): 4.02e-77: 244: 15.44
+	Hs
		629061 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNA2_HUMAN (10-271): 4.73e-74: 238: 17.49
+	Hs
		325481 CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00		CCNB2_HUMAN (5-287): 4.02e-77: 244: 15.44
+	Hs
		629100 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		CCNA2_HUMAN (10-271): 4.73e-74: 238: 17.49
+	Hs
		629102 CDK5_HUMAN (1-292): 1.13e-137: 391: 100.00		CCNA2_HUMAN (10-271): 4.73e-74: 238: 17.49
+	Hs
		667667 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNG1_HUMAN (8-253): 5.3e-71: 225: 28.06
+	Hs
		666939 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNE1_HUMAN (3-298): 7.26e-67: 218: 19.06
+	Rn
		1048464 Q6P751_RAT (1-292): 7.07e-142: 402: 59.73		CCND2_RAT (15-271): 2.72e-66: 213: 21.64
+	Hs
		666973 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		CCNE1_HUMAN (3-298): 7.26e-67: 218: 19.06
+	Rn
		73333 Q6P751_RAT (1-292): 7.07e-142: 402: 59.73		B1WC54_RAT (17-256): 1.66e-57: 194: 24.51
+	Xl
		205903 CDK2_XENLA (1-292): 2.96e-141: 401: 59.73		CCNE3_XENLA (25-208): 3.65e-54: 185: 27.03
+	Hs
		355336 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		CCNE2_HUMAN (37-207): 9.15e-53: 181: 30.64
+	Hs
		667944 CDK2_HUMAN (1-292): 7.63e-142: 402: 59.39		Q8WUE3_HUMAN (37-207): 1.92e-52: 180: 30.64
+	Hs
		355344 CDK3_HUMAN (1-291): 1.01e-139: 397: 61.30		CCNE2_HUMAN (37-207): 9.15e-53: 181: 30.64