HitPredict

Interactor 1: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 594 Hs			1 974
+	Hs
		1031708 GRB10_HUMAN (1-594): 0: 712: 100.00		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		924602 GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89		RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46
+	Hs
		196942 LYN_HUMAN (409-593): 7.45e-46: 171: 17.19		PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85
+	Hs
		196966 FRK_HUMAN (438-594): 3.18e-45: 169: 20.38		PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85
+	Hs
		433921 LYN_HUMAN (409-593): 7.45e-46: 171: 17.19		PHIP_HUMAN (222-463): 1.44e-20: 100: 10.57
+	Hs
		412300 FYN_HUMAN (441-591): 5.64e-47: 174: 20.38		SNR40_HUMAN (268-503): 1.87e-17: 87.2: 9.09
+	Hs
		924823 GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60