HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCTD2 (Q14681)
BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)
Gene: KCTD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	28060381, 34342229, 28514442, 34878901, 35563538, 21145461, 30190310
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 263
+	Hs
		1042675 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81
+	Hs
		1042035 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13
+	Hs
		1042523 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD3_HUMAN (37-253): 1.35e-55: 182: 24.77
+	Hs
		1041533 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD2_HUMAN (59-253): 3.28e-53: 176: 26.53
+	Hs
		1042165 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD1_HUMAN (52-252): 4.42e-53: 176: 23.27
+	Hs
		1041881 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD1_HUMAN (27-199): 1.4e-43: 150: 27.84
+	Hs
		1041705 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD21_HUMAN (70-173): 7.25e-43: 148: 31.43
+	Hs
		1041891 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD9_HUMAN (62-215): 7.43e-41: 146: 35.48
+	Hs
		1042096 CUL3_HUMAN (1-768): 0: 951: 100.00		SHKB1_HUMAN (57-183): 2.75e-35: 135: 40.95
+	Hs
		1042934 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD3_HUMAN (65-183): 4.89e-34: 131: 42.02
+	Hs
		1042242 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD12_HUMAN (65-167): 3.74e-33: 124: 35.58
+	Dm
		1213854 Q8IP45_DROME (17-768): 0: 868: 69.08		Q9W579_DROME (60-263): 8.64e-62: 195: 57.84
+	Ce
		1088878 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18776_CAEEL (67-260): 7.52e-60: 192: 56.41
+	Ce
		954547 CUL3_CAEEL (4-768): 0: 792: 48.08		P91563_CAEEL (70-254): 1.13e-43: 149: 26.43
+	Ce
		1088887 CUL3_CAEEL (4-768): 0: 792: 48.08		Q965M5_CAEEL (68-174): 2.23e-40: 140: 33.33
+	Ce
		109385 CUL3_CAEEL (4-768): 0: 792: 48.08		H2KY83_CAEEL (70-227): 2.27e-39: 136: 25.63
+	Ce
		184054 CUL3_CAEEL (4-768): 0: 792: 48.08		O16612_CAEEL (70-182): 1.56e-38: 135: 28.07
+	Ce
		1088879 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18986_CAEEL (70-177): 6.32e-35: 127: 31.19
+	Hs
		1043508 CUL4B_HUMAN (5-768): 0: 779: 36.77		KCD12_HUMAN (65-167): 3.74e-33: 124: 35.58
+	Hs
		1041480 CUL2_HUMAN (30-768): 0: 672: 26.17		KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81