HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1233
+	Hs
		311540 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57
+	Hs
		1042636 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90
+	Hs
		1042984 CUL4A_HUMAN (10-768): 0: 791: 38.32		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		1042860 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Mm
		56802 CUL4B_MOUSE (5-768): 0: 779: 36.64		SMC1A_MOUSE (1-1233): 1.34e-128: 427: 99.84
+	Hs
		724816 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62
+	Hs
		1043311 CUL4A_HUMAN (10-768): 0: 791: 38.32		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		1041506 CUL2_HUMAN (30-768): 0: 672: 26.17		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		724815 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62