HitPredict

Interactor 1: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Interactor 2: SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Gene: SIK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33961781, 36931259, 22588126, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1321
+	Hs
		972160 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK3_HUMAN (1-1321): 0: 1287: 100.00
+	Hs
		692031 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK3_HUMAN (1-706): 5.66e-155: 487: 31.29
+	Mm
		972206 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK3_MOUSE (1-706): 5.43e-155: 487: 31.71
+	Hs
		971985 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK2_HUMAN (50-831): 2.4e-151: 482: 34.92
+	Xl
		237423 O57468_XENLA (1-244): 9.77e-141: 396: 62.71		Q804T2_XENLA (1-706): 1.72e-151: 476: 32.44
+	Hs
		971697 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK2_HUMAN (15-704): 8.01e-144: 458: 30.93
+	Mm
		972209 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK2_MOUSE (15-704): 1.17e-143: 457: 30.37
+	Mm
		972284 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK4_MOUSE (1-716): 1.83e-143: 456: 30.90
+	Xl
		237424 O57468_XENLA (1-244): 9.77e-141: 396: 62.71		Q8QGV3_XENLA (1-705): 8.67e-143: 455: 30.46
+	Hs
		971885 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK4_HUMAN (1-716): 1.71e-142: 453: 30.76
+	Dm
		94942 1433E_DROME (1-243): 8e-141: 396: 63.37		E1JGN0_DROME (9-627): 4.56e-138: 453: 34.25
+	At
		1030844 14332_ARATH (4-244): 8.76e-141: 396: 60.91		CDPK1_ARATH (2-504): 5.92e-143: 450: 23.40
+	At
		854983 14334_ARATH (4-244): 5.39e-139: 392: 60.49		CDPK1_ARATH (2-504): 5.92e-143: 450: 23.40
+	Hs
		943639 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK1_HUMAN (50-800): 7.05e-138: 442: 32.42
+	Hs
		972043 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SNRK_HUMAN (52-427): 1.21e-137: 441: 38.85
+	Hs
		930668 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		AAPK2_HUMAN (52-597): 1.39e-138: 436: 30.13
+	Mm
		972294 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK1_MOUSE (35-488): 8.21e-134: 431: 44.35
+	Hs
		972078 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK1_HUMAN (41-382): 1.93e-105: 354: 55.43
+	Hs
		971753 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		BRSK2_HUMAN (63-398): 9.47e-78: 275: 43.49
+	Mm
		972247 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		BRSK2_MOUSE (63-398): 5.8e-78: 275: 43.49