HitPredict

Interactor 1: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Interactor 2: DPYL2 (Q16555)
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene: DPYSL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	28514442, 29892012, 33961781, 25416956, 32296183, 35235311, 34349018, unassigned1304, 31515488
Identification Methods	affinity chromatography technology, two hybrid, cross-linking study, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation, mammalian protein protein interaction trap
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0005829 - cytosol GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 570 Hs			1 572
+	Hs
		1083118 Q8IXW6_HUMAN (1-570): 0: 765: 99.83		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Hs
		1050861 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		1050867 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Mm
		956446 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL1_MOUSE (1-572): 0: 752: 76.22
+	Hs
		1083101 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Hs
		1050860 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Mm
		139071 DPYL2_MOUSE (1-569): 0: 740: 77.41		DPYL2_MOUSE (1-572): 0: 768: 98.78
+	Rn
		815101 DPYL2_RAT (1-569): 0: 740: 77.41		DPYL2_RAT (1-572): 0: 768: 98.78
+	Hs
		147332 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		147331 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		147335 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		1083161 DPYL2_HUMAN (1-569): 0: 742: 76.71		X5DQV1_HUMAN (14-572): 0: 733: 76.03
+	Hs
		1050937 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Hs
		1048471 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYS_HUMAN (13-528): 0: 651: 59.04
+	Mm
		1143651 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL5_MOUSE (9-567): 0: 647: 50.62
+	Hs
		1083135 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Hs
		1048473 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYS_HUMAN (13-528): 0: 651: 59.04