HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28188290
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 533
+	Mm
		236898 ACK1_MOUSE (1-1038): 0: 787: 92.70		LCP2_MOUSE (1-531): 1.4e-72: 242: 80.98
+	Hs
		1094302 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		440526 FYN_HUMAN (1-400): 2.05e-126: 397: 29.60		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Mm
		813521 FYN_MOUSE (1-400): 3.71e-126: 396: 29.60		LCP2_MOUSE (1-531): 1.4e-72: 242: 80.98
+	Hs
		1145741 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		TENS2_HUMAN (76-512): 1.92e-30: 128: 17.42
+	Hs
		1145742 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Mm
		813537 FYN_MOUSE (1-400): 3.71e-126: 396: 29.60		CLNK_MOUSE (150-528): 1.67e-36: 142: 28.13
+	Hs
		1145748 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		TENS4_HUMAN (189-512): 1.18e-26: 116: 16.52
+	Rn
		98572 Q9QX70_RAT (83-606): 5.95e-119: 396: 27.57		F1LN91_RAT (104-512): 5.26e-34: 139: 13.00
+	Hs
		1051009 FAK1_HUMAN (6-692): 2.66e-125: 409: 20.60		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Hs
		932087 EPHA4_HUMAN (87-486): 2.84e-125: 408: 24.52		TENS3_HUMAN (83-512): 2.88e-29: 125: 12.50
+	Hs
		176239 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		SYNJ2_HUMAN (125-443): 2.57e-09: 62.3: 11.77
+	Hs
		362149 ABL1_HUMAN (1-975): 2.91e-146: 467: 19.01		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88
+	Hs
		1145782 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		TENS1_HUMAN (85-512): 6.08e-23: 105: 14.61
+	Hs
		440813 FYN_HUMAN (1-400): 2.05e-126: 397: 29.60		MYO16_HUMAN (44-389): 5.38e-27: 118: 14.76
+	Hs
		440737 FYN_HUMAN (1-400): 2.05e-126: 397: 29.60		TENS1_HUMAN (85-512): 6.08e-23: 105: 14.61
+	Hs
		590283 ERBB4_HUMAN (84-754): 2.43e-127: 420: 22.69		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88
+	Hs
		440773 FYN_HUMAN (1-400): 2.05e-126: 397: 29.60		MAGL2_HUMAN (60-476): 1.92e-10: 65.8: 10.50
+	Hs
		176240 FYN_HUMAN (1-400): 2.05e-126: 397: 29.60		SYNJ2_HUMAN (125-443): 2.57e-09: 62.3: 11.77
+	Hs
		557066 SRC_HUMAN (1-400): 7.1e-125: 393: 31.67		MUC1_HUMAN (191-473): 9.08e-09: 60.4: 10.88