HitPredict

Interactor 1: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.767

The method score is based on:

Property Details
Experiments 23034801, 21430779
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pre-SET~Pre-SET, Pre-SET~SET, Ank~SET
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0046974 - histone H3K9 methyltransferase activity
GO:0140947 - histone H3K9me2 methyltransferase activity
and 1 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1291
Hs

1 1210
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024