Protein: CLSPN
Claspin (hClaspin)

Gene: CLSPN
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9HAW4

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000077 - DNA damage checkpoint signaling
GO:0000217 - DNA secondary structure binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154243

CHK1
Serine/threonine-protein kinase Chk1

12

2

Small-scale

0.761

High

1335002

FBW1B
F-box/WD repeat-containing protein 11

6

7

Small-scale

0.721

High

1335007

FBW1A
F-box/WD repeat-containing protein 1A

6

7

Small-scale

0.721

High

1335004

FZR1
Fizzy-related protein homolog

3

7

Small-scale

0.675

High

1335005

TIM
Protein timeless homolog

3

1

Small-scale

0.664

High

553758

RFA2
Replication protein A 32 kDa subunit

3

3

Small-scale

0.656

High

652297

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

2

Small-scale

0.656

High

264237

CDC45
Cell division control protein 45 homolog

3

0

Small-scale

0.652

High

125920

CDC7
Cell division cycle 7-related protein kinase

2

6

Small-scale

0.646

High

861933

PLK1
Serine/threonine-protein kinase PLK1

3

2

Small-scale

0.640

High

1310749

PSF3
DNA replication complex GINS protein PSF3

3

0

High-throughput

0.638

High

1305392

RAD9A
Cell cycle checkpoint control protein RAD9A

3

0

Small-scale

0.622

High

721488

RFA3
Replication protein A 14 kDa subunit

2

2

Small-scale

0.611

High

832722

MCM2
DNA replication licensing factor MCM2

2

1

Small-scale

0.611

High

279043

RAD17
Cell cycle checkpoint protein RAD17

2

0

Small-scale

0.598

High

1314298

TIPIN
TIMELESS-interacting protein

2

0

Small-scale

0.598

High

1335008

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

1

Small-scale

0.596

High

749865

BRCA1
Breast cancer type 1 susceptibility protein

2

6

Small-scale

0.595

High

320014

HERC2
E3 ubiquitin-protein ligase HERC2

2

2

Small-scale

0.584

High

347935

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

517473

PCNA
Proliferating cell nuclear antigen

2

1

Small-scale

0.584

High

1273888

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.561

High

1334996

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

2

Small-scale

0.561

High

1038174

ATR
Serine/threonine-protein kinase ATR

2

0

Small-scale

0.559

High

841888

CDK9
Cyclin-dependent kinase 9

1

5

Small-scale

0.554

High

585072

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

992318

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.537

High

996903

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

535941

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

739840

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

1297510

PRIPO
DNA-directed primase/polymerase protein

1

0

Small-scale

0.513

High

1332628

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

876963

CASP7
Caspase-7

1

3

Small-scale

0.501

High

943163

KC1G2
Casein kinase I isoform gamma-2

1

3

Small-scale

0.501

High

1334997

KC1G1
Casein kinase I isoform gamma-1

1

2

Small-scale

0.501

High

1335009

KC1G3
Casein kinase I isoform gamma-3

1

4

Small-scale

0.501

High

361246

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.489

High

522646

MYH7
Myosin-7

1

1

High-throughput

0.489

High

179830

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

238438

JAK2
Tyrosine-protein kinase JAK2

1

5

High-throughput

0.479

High

274383

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

6

Small-scale

0.479

High

387541

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

391911

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

411497

INSR
Insulin receptor

1

11

High-throughput

0.479

High

455890

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

575585

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

647685

MK03
Mitogen-activated protein kinase 3

1

2

High-throughput

0.479

High

659059

MK01
Mitogen-activated protein kinase 1

1

2

High-throughput

0.479

High

836002

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.479

High

903529

WDR5
WD repeat-containing protein 5

1

6

Small-scale

0.479

High

1017442

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.479

High

1027270

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1042574

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1222584

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1265899

DDB2
DNA damage-binding protein 2

1

7

Small-scale

0.479

High

1282713

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

3

High-throughput

0.479

High

1301519

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

5

Small-scale

0.479

High

1334995

SP110
Sp110 nuclear body protein

1

6

High-throughput

0.479

High

1334998

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.479

High

1334999

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1335001

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1335006

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

163307

XPO1
Exportin-1

1

0

High-throughput

0.458

High

855556

MSH6
DNA mismatch repair protein Msh6

1

0

Small-scale

0.458

High

869890

PMS2
Mismatch repair endonuclease PMS2

1

0

Small-scale

0.458

High

931875

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

967082

XPC
DNA repair protein complementing XP-C cells

1

0

Small-scale

0.458

High

1134080

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1138371

CBPC6
Cytosolic carboxypeptidase 6

1

0

Small-scale

0.458

High

1161840

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1266685

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1335000

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1335003

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

435767

IGF1R
Insulin-like growth factor 1 receptor

1

8

High-throughput

0.437

High

830796

ARL4D
ADP-ribosylation factor-like protein 4D

1

8

High-throughput

0.437

High

1002069

ARL16
ADP-ribosylation factor-like protein 16

1

6

High-throughput

0.437

High

1220286

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.437

High

1313533

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.437

High

1217198

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

296980

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

661188

CXB2
Gap junction beta-2 protein

1

0

High-throughput

0.279

Low

828905

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

958851

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.279

Low

352426

TNFB
Lymphotoxin-alpha

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024