HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30209976
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 1191
+	Hs
		1031467 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		516698 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1329984 PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1084482 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1031360 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		516550 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136287 PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1056844 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21
+	Hs
		1084554 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		CBP_HUMAN (556-893): 1.74e-09: 64.6: 9.77
+	Hs
		847103 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		CHD7_HUMAN (491-1004): 4.82e-13: 76.2: 7.21
+	Hs
		846837 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		CBP_HUMAN (556-893): 1.74e-09: 64.6: 9.77
+	Dm
		375643 BRM_DROME (249-551): 1.19e-45: 175: 20.72		RPB1_DROME (644-998): 4.65e-09: 63.1: 10.28
+	Hs
		847041 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		CBP_HUMAN (556-893): 1.74e-09: 64.6: 9.77
+	Hs
		516595 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		KMT2C_HUMAN (351-895): 4.49e-14: 79.7: 9.35
+	Hs
		302269 SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25		SC24C_HUMAN (362-642): 1.58e-09: 64.6: 12.98
+	Mm
		1351630 PCLO_MOUSE (195-468): 6.01e-14: 77.6: 11.31		PCLO_MOUSE (522-1015): 6.21e-15: 82.8: 8.09
+	Mm
		57185 SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30		CHD7_MOUSE (412-954): 1.27e-16: 88.2: 7.87
+	Dm
		113976 M9PB30_DROME (190-412): 1.36e-12: 73: 16.67		M9PB30_DROME (683-1171): 5.39e-11: 69.7: 12.25
+	Hs
		325765 TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18		LATS1_HUMAN (518-1066): 1.1e-09: 65: 11.05
+	Hs
		867103 TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18		SC24C_HUMAN (362-642): 1.58e-09: 64.6: 12.98