Protein: RRP42
Exosome complex component RRP42 (Ribosomal RNA-processing protein 42)

Gene: RRP42
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: Q12277

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1061961

RRP44
Exosome complex exonuclease DIS3

11

19

Small-scale

0.757

High

871143

MTR3
Exosome complex component MTR3

9

2

Small-scale

0.757

High

1084419

RRP6
Exosome complex exonuclease RRP6

12

11

Small-scale

0.756

High

924003

CSL4
Exosome complex component CSL4

10

12

Small-scale

0.754

High

918914

RRP46
Exosome complex component RRP46

10

20

Small-scale

0.754

High

863154

RRP41
Exosome complex component SKI6

8

20

Small-scale

0.748

High

1051729

RRP45
Exosome complex component RRP45

6

17

Small-scale

0.730

High

804769

RRP4
Exosome complex component RRP4

5

20

Small-scale

0.714

High

672984

RRP43
Exosome complex component RRP43

5

2

Small-scale

0.712

High

922965

MPP6
M-phase phosphoprotein 6 homolog

4

2

Small-scale

0.696

High

1064325

SKI7
Superkiller protein 7

7

7

Small-scale

0.679

High

1062921

RRP40
Exosome complex component RRP40

3

12

Small-scale

0.656

High

798356

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.640

High

1046093

DHR1
Probable ATP-dependent RNA helicase DHR1

3

3

High-throughput

0.640

High

609089

SKI3
Superkiller protein 3

2

4

High-throughput

0.611

High

763653

UTP20
U3 small nucleolar RNA-associated protein 20

2

2

High-throughput

0.611

High

677623

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

844665

UTP10
U3 small nucleolar RNA-associated protein 10

2

2

High-throughput

0.584

High

1046827

UTP14
U3 small nucleolar RNA-associated protein 14

2

3

High-throughput

0.584

High

1055526

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

1050211

RRP5
rRNA biogenesis protein RRP5

2

5

High-throughput

0.571

High

546771

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

820136

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

917512

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

1

High-throughput

0.541

High

623978

MYO2
Myosin-2

2

1

High-throughput

0.537

High

865290

LSM8
LSM2-LSM8 complex subunit LSM8

1

7

High-throughput

0.536

High

1039073

IMA1
Importin subunit alpha

1

2

High-throughput

0.515

High

509763

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

438171

NOT2
General negative regulator of transcription subunit 2

1

2

Small-scale

0.479

High

673254

RRP7
Ribosomal RNA-processing protein 7

1

2

High-throughput

0.479

High

678487

PWP2
Periodic tryptophan protein 2

1

12

High-throughput

0.479

High

708551

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

754357

DCA13
Protein SOF1

1

9

High-throughput

0.479

High

758428

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

761146

NOT4
General negative regulator of transcription subunit 4

1

1

Small-scale

0.479

High

776674

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.479

High

804977

LRP1
Exosome complex protein LRP1

1

2

High-throughput

0.479

High

806599

UTP9
U3 small nucleolar RNA-associated protein 9

1

2

High-throughput

0.479

High

817657

UTP7
U3 small nucleolar RNA-associated protein 7

1

6

High-throughput

0.479

High

823411

UTP18
U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.479

High

826231

FAF1
Protein FAF1

1

2

High-throughput

0.479

High

836218

DIM1
Dimethyladenosine transferase

1

1

High-throughput

0.479

High

864558

MTR4
ATP-dependent RNA helicase DOB1

1

16

High-throughput

0.479

High

865195

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

871078

NOL10
Ribosome biogenesis protein ENP2

1

1

High-throughput

0.479

High

918860

UTP22
U3 small nucleolar RNA-associated protein 22

1

3

High-throughput

0.479

High

919198

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.479

High

919293

CF130
Protein CAF130

1

1

Small-scale

0.479

High

924666

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

925144

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

925220

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

1036433

UTP6
U3 small nucleolar RNA-associated protein 6

1

2

High-throughput

0.479

High

1039878

UTP17
NET1-associated nuclear protein 1

1

14

High-throughput

0.479

High

1045128

UTP5
U3 small nucleolar RNA-associated protein 5

1

11

High-throughput

0.479

High

1046278

UTP15
U3 small nucleolar RNA-associated protein 15

1

8

High-throughput

0.479

High

1051177

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1053136

UTP13
U3 small nucleolar RNA-associated protein 13

1

16

High-throughput

0.479

High

1053538

UTP21
U3 small nucleolar RNA-associated protein 21

1

14

High-throughput

0.479

High

1054559

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

2

High-throughput

0.479

High

1055450

RRP9
Ribosomal RNA-processing protein 9

1

12

High-throughput

0.479

High

1056330

BFR2
Protein BFR2

1

2

High-throughput

0.479

High

1056499

UTP4
U3 small nucleolar RNA-associated protein 4

1

10

High-throughput

0.479

High

1061648

RCL1
rRNA processing protein RCL1

1

2

High-throughput

0.479

High

1064332

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.479

High

1065602

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

1084164

FCF2
rRNA-processing protein FCF2

1

3

High-throughput

0.479

High

1084353

SAS10
Something about silencing protein 10

1

3

High-throughput

0.479

High

1084626

UTP12
U3 small nucleolar RNA-associated protein 12

1

15

High-throughput

0.479

High

1084706

RRP42
Exosome complex component RRP42

1

18

Small-scale

0.479

High

1084707

NOP56
Nucleolar protein 56

1

7

High-throughput

0.479

High

1084708

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

1084709

RRP12
Ribosomal RNA-processing protein 12

1

2

High-throughput

0.479

High

1084711

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

782121

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

825100

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

1084464

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

382414

H4
Histone H4

1

1

High-throughput

0.445

High

403704

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

528034

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

676998

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.445

High

503865

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

453848

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.407

High

752892

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

893262

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

3

High-throughput

0.407

High

760547

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

0

High-throughput

0.269

Low

812772

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

1084710

RS22B
Small ribosomal subunit protein uS8B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025