HitPredict

Interactor 1: NMDE1 (Q12879)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
Gene: GRIN2A

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19086921
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0014069 - postsynaptic density GO:0043197 - dendritic spine GO:0048168 - regulation of neuronal synaptic plasticity GO:0060291 - long-term synaptic potentiation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1464 Hs			1 478
+	Rn
		540147 NMDE1_RAT (1-1464): 0: 1762: 95.22		KCC2A_RAT (1-478): 0: 570: 99.79
+	Rn
		586061 NMDE1_RAT (1-1464): 0: 1762: 95.22		KCC2D_RAT (2-476): 0: 540: 80.32
+	Hs
		1098539 NMDE2_HUMAN (4-1464): 0: 1535: 52.95		KCC2A_HUMAN (1-478): 0: 570: 100.00
+	Rn
		540148 NMDE2_RAT (4-1464): 0: 1522: 52.82		KCC2A_RAT (1-478): 0: 570: 99.79
+	Mm
		548944 NMDE2_MOUSE (4-1464): 0: 1519: 52.82		KCC2A_MOUSE (1-478): 0: 570: 99.79
+	Rn
		586062 NMDE2_RAT (4-1464): 0: 1522: 52.82		KCC2D_RAT (2-476): 0: 540: 80.32
+	Mm
		704211 NMDE2_MOUSE (4-1464): 0: 1519: 52.82		KCC2B_MOUSE (1-476): 1.13e-179: 515: 71.11
+	Hs
		1098518 NMDE2_HUMAN (4-1464): 0: 1535: 52.95		KCC2G_HUMAN (276-476): 9.73e-33: 132: 53.23
+	Hs
		838473 GRIA1_HUMAN (13-911): 0: 682: 19.20		KCC2A_HUMAN (1-478): 0: 570: 100.00
+	Rn
		540122 GRIA1_RAT (13-878): 0: 680: 19.24		KCC2A_RAT (1-478): 0: 570: 99.79
+	Mm
		548935 NMDZ1_MOUSE (8-940): 0: 673: 23.24		KCC2A_MOUSE (1-478): 0: 570: 99.79
+	Hs
		1051689 NMDZ1_HUMAN (8-940): 0: 670: 23.30		KCC2A_HUMAN (1-478): 0: 570: 100.00
+	Hs
		870111 GRIA4_HUMAN (15-863): 0: 658: 18.59		KCC2A_HUMAN (1-478): 0: 570: 100.00
+	Mm
		704206 NMDZ1_MOUSE (8-940): 0: 673: 23.24		KCC2B_MOUSE (1-476): 1.13e-179: 515: 71.11
+	Rn
		548658 GRIA4_RAT (15-863): 0: 657: 18.59		KCC2G_RAT (1-476): 0: 526: 76.00
+	Mm
		704218 GRID2_MOUSE (74-889): 4.19e-179: 562: 22.04		KCC2B_MOUSE (1-476): 1.13e-179: 515: 71.11
+	Hs
		1051659 NMDZ1_HUMAN (8-940): 0: 670: 23.30		KCC2G_HUMAN (276-476): 9.73e-33: 132: 53.23