HitPredict

Interactor 1: KCC2A (P11798)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: Camk2a

Interactor 2: NMDE2 (Q01097)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)
Gene: Grin2b

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	31914378, 24734203, 22044428, 20141836, 10862698, 16710293, 22234183, 24725413
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006816 - calcium ion transport GO:0014069 - postsynaptic density GO:0045202 - synapse GO:0048168 - regulation of neuronal synaptic plasticity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 478 Mm			1 1482
+	Hs
		1098518 KCC2G_HUMAN (1-475): 0: 612: 71.35		NMDE2_HUMAN (1-1482): 0: 1835: 98.38
+	Rn
		540148 KCC2A_RAT (1-478): 0: 567: 100.00		NMDE2_RAT (1-1482): 0: 1852: 99.46
+	Hs
		1098539 KCC2A_HUMAN (1-478): 0: 567: 99.79		NMDE2_HUMAN (1-1482): 0: 1835: 98.38
+	Rn
		586062 KCC2D_RAT (2-476): 0: 536: 80.32		NMDE2_RAT (1-1482): 0: 1852: 99.46
+	Mm
		704211 KCC2B_MOUSE (1-476): 8.41e-180: 516: 70.93		NMDE2_MOUSE (1-1482): 0: 1854: 100.00
+	Rn
		540147 KCC2A_RAT (1-478): 0: 567: 100.00		NMDE1_RAT (9-1482): 0: 1503: 52.58
+	Hs
		1088797 KCC2A_HUMAN (1-478): 0: 567: 99.79		NMDE1_HUMAN (9-1482): 0: 1495: 52.38
+	Rn
		586061 KCC2D_RAT (2-476): 0: 536: 80.32		NMDE1_RAT (9-1482): 0: 1503: 52.58
+	Hs
		1051659 KCC2G_HUMAN (1-475): 0: 612: 71.35		NMDZ1_HUMAN (14-940): 0: 673: 23.54
+	Rn
		540122 KCC2A_RAT (1-478): 0: 567: 100.00		GRIA1_RAT (11-901): 0: 687: 19.92
+	Hs
		838473 KCC2A_HUMAN (1-478): 0: 567: 99.79		GRIA1_HUMAN (14-901): 0: 685: 19.90
+	Mm
		548935 KCC2A_MOUSE (1-478): 0: 567: 100.00		NMDZ1_MOUSE (14-940): 0: 676: 23.44
+	Hs
		1051689 KCC2A_HUMAN (1-478): 0: 567: 99.79		NMDZ1_HUMAN (14-940): 0: 673: 23.54
+	Hs
		870111 KCC2A_HUMAN (1-478): 0: 567: 99.79		GRIA4_HUMAN (17-878): 0: 653: 21.06
+	Mm
		704206 KCC2B_MOUSE (1-476): 8.41e-180: 516: 70.93		NMDZ1_MOUSE (14-940): 0: 676: 23.44
+	Rn
		548658 KCC2G_RAT (1-476): 0: 523: 75.81		GRIA4_RAT (17-852): 0: 649: 21.23