HitPredict

Interactor 1: KCC2D (P15791)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: Camk2d

Interactor 2: NMDE1 (Q00959)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)
Gene: Grin2a

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12147342
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006816 - calcium ion transport GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0048168 - regulation of neuronal synaptic plasticity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 533 Rn			1 1464
+	Rn
		540147 KCC2A_RAT (1-511): 0: 553: 80.82		NMDE1_RAT (1-1464): 0: 1774: 100.00
+	Hs
		1088797 KCC2A_HUMAN (1-511): 0: 553: 80.82		NMDE1_HUMAN (1-1464): 0: 1692: 95.22
+	Rn
		586062 KCC2D_RAT (1-533): 0: 643: 100.00		NMDE2_RAT (4-1464): 0: 1519: 52.85
+	Mm
		704211 KCC2B_MOUSE (1-512): 0: 573: 77.31		NMDE2_MOUSE (4-1464): 0: 1511: 52.72
+	Rn
		540148 KCC2A_RAT (1-511): 0: 553: 80.82		NMDE2_RAT (4-1464): 0: 1519: 52.85
+	Mm
		548944 KCC2A_MOUSE (1-511): 0: 553: 80.82		NMDE2_MOUSE (4-1464): 0: 1511: 52.72
+	Hs
		1098518 KCC2G_HUMAN (1-512): 0: 553: 77.06		NMDE2_HUMAN (4-1464): 0: 1501: 52.65
+	Hs
		1098539 KCC2A_HUMAN (1-511): 0: 553: 80.82		NMDE2_HUMAN (4-1464): 0: 1501: 52.65
+	Mm
		704206 KCC2B_MOUSE (1-512): 0: 573: 77.31		NMDZ1_MOUSE (7-940): 0: 671: 23.13
+	Rn
		540122 KCC2A_RAT (1-511): 0: 553: 80.82		GRIA1_RAT (13-912): 0: 687: 19.71
+	Hs
		838473 KCC2A_HUMAN (1-511): 0: 553: 80.82		GRIA1_HUMAN (13-912): 0: 683: 19.81
+	Mm
		548935 KCC2A_MOUSE (1-511): 0: 553: 80.82		NMDZ1_MOUSE (7-940): 0: 671: 23.13
+	Rn
		548658 KCC2G_RAT (1-512): 0: 566: 78.94		GRIA4_RAT (15-863): 0: 657: 19.12
+	Hs
		1051659 KCC2G_HUMAN (1-512): 0: 553: 77.06		NMDZ1_HUMAN (13-940): 0: 666: 23.17
+	Hs
		1051689 KCC2A_HUMAN (1-511): 0: 553: 80.82		NMDZ1_HUMAN (13-940): 0: 666: 23.17
+	Hs
		870111 KCC2A_HUMAN (1-511): 0: 553: 80.82		GRIA4_HUMAN (15-863): 0: 661: 19.34