HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30561431
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 1055
+	Mm
		944132 TRAF5_MOUSE (7-501): 7.67e-115: 351: 29.62		UBP25_MOUSE (1-1055): 0: 1027: 93.85
+	Hs
		136734 TRAF5_HUMAN (7-501): 5.44e-116: 354: 30.90		UBP25_HUMAN (1-1055): 0: 1023: 100.00
+	Mm
		944136 TRAF3_MOUSE (9-501): 1.09e-111: 343: 31.75		UBP25_MOUSE (1-1055): 0: 1027: 93.85
+	Hs
		1095003 TRAF3_HUMAN (16-501): 1.77e-110: 340: 31.42		UBP25_HUMAN (1-1055): 0: 1023: 100.00
+	Mm
		944133 TRAF6_MOUSE (2-498): 9.49e-108: 332: 27.47		UBP25_MOUSE (1-1055): 0: 1027: 93.85
+	Hs
		1460020 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP25_HUMAN (1-1055): 0: 1023: 100.00
+	Hs
		1090756 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		UBP48_HUMAN (157-406): 1.38e-66: 245: 25.86
+	Hs
		853547 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP5_HUMAN (58-656): 1.12e-83: 291: 14.26
+	Hs
		1090836 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		1090727 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		U17L2_HUMAN (577-732): 1.73e-17: 89.2: 22.15
+	Hs
		288400 TRAF2_HUMAN (1-501): 1.2e-158: 461: 100.00		UBP2_HUMAN (514-655): 1.22e-14: 80.4: 18.31
+	Hs
		1094958 TRAF3_HUMAN (16-501): 1.77e-110: 340: 31.42		UBP47_HUMAN (163-418): 1.84e-39: 161: 18.45
+	Mm
		999860 TRAF6_MOUSE (2-498): 9.49e-108: 332: 27.47		UBP47_MOUSE (163-418): 2.01e-39: 161: 18.45
+	Hs
		1395789 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP47_HUMAN (163-418): 1.84e-39: 161: 18.45
+	Hs
		136715 TRAF5_HUMAN (7-501): 5.44e-116: 354: 30.90		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		1094946 TRAF3_HUMAN (16-501): 1.77e-110: 340: 31.42		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		1094913 TRAF3_HUMAN (16-501): 1.77e-110: 340: 31.42		U17L2_HUMAN (577-732): 1.73e-17: 89.2: 22.15
+	Hs
		1371803 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		288551 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP2_HUMAN (514-655): 1.22e-14: 80.4: 18.31
+	Hs
		1491433 TRAF6_HUMAN (2-498): 9.71e-106: 327: 27.08		UBP3_HUMAN (581-660): 8.62e-11: 67.6: 32.10