HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCTD5 (Q9NXV2)
BTB/POZ domain-containing protein KCTD5
Gene: KCTD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	18573101, 34342229, 26334369, 28963344, 33130828, 32876072, 34878901, 35563538, 37495603, 21145461, 24747150
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BTB_2~Cullin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 234
+	Hs
		1113115 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD2_HUMAN (11-234): 4.25e-71: 219: 71.56
+	Hs
		1113692 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD17_HUMAN (44-225): 8.03e-59: 189: 78.57
+	Hs
		1114281 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD3_HUMAN (12-224): 4.14e-56: 182: 21.96
+	Hs
		1113060 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD2_HUMAN (24-224): 6.75e-54: 177: 22.28
+	Mm
		1296400 CUL3_MOUSE (1-768): 0: 941: 99.48		BACD1_MOUSE (14-223): 1.68e-54: 179: 22.02
+	Hs
		1113860 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD1_HUMAN (26-223): 1.31e-51: 171: 23.62
+	Hs
		1113539 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD20_HUMAN (3-231): 5.53e-46: 159: 17.81
+	Hs
		1114759 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD3_HUMAN (20-138): 7.06e-41: 150: 38.66
+	Hs
		1113506 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD9_HUMAN (40-159): 4.01e-41: 146: 44.63
+	Hs
		1114037 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD7_HUMAN (34-152): 2.83e-40: 141: 31.93
+	Hs
		1113259 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD21_HUMAN (42-160): 4.12e-40: 140: 30.00
+	Hs
		1113494 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD1_HUMAN (31-161): 3.51e-40: 140: 24.81
+	Hs
		1113946 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD12_HUMAN (19-174): 7.32e-39: 138: 24.84
+	Hs
		1113774 CUL3_HUMAN (1-768): 0: 943: 100.00		SHKB1_HUMAN (40-150): 8.3e-36: 135: 40.54
+	Dm
		1304397 Q8IP45_DROME (17-768): 0: 857: 69.08		Q9W579_DROME (40-234): 8.73e-60: 189: 63.08
+	Ce
		1164803 CUL3_CAEEL (4-768): 0: 787: 48.08		Q18776_CAEEL (40-231): 9.03e-59: 188: 55.44
+	Hs
		1115352 CUL4B_HUMAN (5-768): 0: 796: 36.77		KCD12_HUMAN (19-174): 7.32e-39: 138: 24.84
+	Ce
		195624 CUL3_CAEEL (4-768): 0: 787: 48.08		O16612_CAEEL (42-223): 5.27e-41: 140: 24.59
+	Ce
		1019184 CUL3_CAEEL (4-768): 0: 787: 48.08		P91563_CAEEL (42-172): 6.4e-40: 139: 32.58
+	Ce
		115045 CUL3_CAEEL (4-768): 0: 787: 48.08		H2KY83_CAEEL (42-200): 3.02e-39: 135: 27.33