HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCD21 (Q4G0X4)
BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Gene: KCTD21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	37495603, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB_2~Cullin
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 260
+	Hs
		1113379 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD11_HUMAN (28-259): 2.02e-67: 210: 37.66
+	Hs
		1114281 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD3_HUMAN (2-195): 1.1e-51: 172: 30.73
+	Hs
		1113506 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD9_HUMAN (3-216): 1.18e-47: 164: 25.76
+	Hs
		1113860 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD1_HUMAN (2-185): 3.67e-45: 155: 32.16
+	Mm
		1296400 CUL3_MOUSE (1-768): 0: 941: 99.48		BACD1_MOUSE (2-185): 1.9e-45: 156: 32.16
+	Hs
		1113060 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD2_HUMAN (3-185): 2.8e-44: 153: 30.61
+	Hs
		1114759 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD3_HUMAN (3-128): 3.21e-38: 143: 35.71
+	Hs
		1114460 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD5_HUMAN (1-109): 1.58e-40: 141: 32.43
+	Hs
		1113774 CUL3_HUMAN (1-768): 0: 943: 100.00		SHKB1_HUMAN (3-131): 2.4e-37: 140: 41.09
+	Hs
		1113692 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD17_HUMAN (3-109): 1.59e-38: 138: 36.11
+	Hs
		1113725 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD6_HUMAN (1-101): 3.34e-39: 138: 69.31
+	Hs
		1114037 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD7_HUMAN (2-112): 5.76e-39: 138: 38.74
+	Hs
		1113115 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD2_HUMAN (4-109): 1.92e-38: 136: 31.19
+	Hs
		1113946 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD12_HUMAN (2-96): 2.01e-37: 135: 45.36
+	Hs
		1113494 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD1_HUMAN (4-107): 1.34e-37: 134: 45.71
+	Hs
		1113436 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD18_HUMAN (3-89): 1.63e-18: 85.9: 44.83
+	Dm
		1304397 Q8IP45_DROME (17-768): 0: 857: 69.08		Q9W579_DROME (2-114): 3.89e-37: 132: 33.04
+	Hs
		1115352 CUL4B_HUMAN (5-768): 0: 796: 36.77		KCD12_HUMAN (2-96): 2.01e-37: 135: 45.36
+	Ce
		115045 CUL3_CAEEL (4-768): 0: 787: 48.08		H2KY83_CAEEL (5-130): 4.23e-40: 138: 25.58
+	Ce
		195624 CUL3_CAEEL (4-768): 0: 787: 48.08		O16612_CAEEL (5-134): 5.61e-39: 136: 25.56