HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCTD7 (Q96MP8)
BTB/POZ domain-containing protein KCTD7
Gene: KCTD7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	30295347, 35921411, 36964131, 37450587, 32296183, 37495603, 22748208, 21145461, unassigned1304
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, two hybrid, tandem affinity purification, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	BTB_2~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 289
+	Hs
		1113494 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD1_HUMAN (27-281): 4.14e-60: 193: 20.08
+	Hs
		1113506 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD9_HUMAN (13-273): 7.61e-47: 163: 17.78
+	Hs
		1113725 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD6_HUMAN (51-262): 3.21e-47: 159: 31.02
+	Hs
		1113259 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD21_HUMAN (50-187): 4.01e-45: 154: 32.62
+	Hs
		1114759 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD3_HUMAN (41-186): 7.61e-41: 152: 27.89
+	Hs
		1113060 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD2_HUMAN (23-181): 3.77e-43: 151: 28.40
+	Mm
		1296400 CUL3_MOUSE (1-768): 0: 941: 99.48		BACD1_MOUSE (13-180): 1.4e-43: 153: 32.95
+	Hs
		1113774 CUL3_HUMAN (1-768): 0: 943: 100.00		SHKB1_HUMAN (47-164): 4.96e-40: 149: 32.77
+	Hs
		1114460 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD5_HUMAN (45-192): 6.97e-43: 148: 25.66
+	Hs
		1114281 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD3_HUMAN (23-178): 1.62e-41: 147: 31.45
+	Hs
		1113860 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD1_HUMAN (33-182): 8.13e-41: 145: 34.84
+	Hs
		1113115 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD2_HUMAN (44-192): 3.38e-41: 144: 23.38
+	Hs
		1113692 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD17_HUMAN (51-186): 1.32e-39: 142: 30.22
+	Hs
		1113946 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD12_HUMAN (44-141): 8.83e-36: 132: 33.01
+	Hs
		1113436 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD18_HUMAN (47-171): 9.24e-32: 123: 31.54
+	Dm
		1304397 Q8IP45_DROME (17-768): 0: 857: 69.08		Q9W579_DROME (39-202): 4.16e-42: 145: 23.35
+	Ce
		195624 CUL3_CAEEL (4-768): 0: 787: 48.08		O16612_CAEEL (53-264): 2.92e-45: 153: 17.21
+	Ce
		1019184 CUL3_CAEEL (4-768): 0: 787: 48.08		P91563_CAEEL (50-235): 8.59e-43: 148: 20.31
+	Hs
		1115352 CUL4B_HUMAN (5-768): 0: 796: 36.77		KCD12_HUMAN (44-141): 8.83e-36: 132: 33.01
+	Ce
		115045 CUL3_CAEEL (4-768): 0: 787: 48.08		H2KY83_CAEEL (53-189): 4.55e-37: 131: 24.11