HitPredict

Interactor 1: PTK6 (Q13882)
Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
Gene: PTK6

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	22974441
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 451 Hs			1 481
+	Hs
		557444 SRC_HUMAN (3-450): 0: 521: 43.30		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		463208 YES_HUMAN (10-450): 0: 519: 42.86		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		473465 HCK_HUMAN (4-449): 7.51e-179: 511: 39.82		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		362358 ABL1_HUMAN (1-449): 1.85e-170: 510: 35.17		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		486706 FGR_HUMAN (10-450): 3.39e-177: 508: 42.41		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		362440 ABL1_MOUSE (1-449): 8.87e-171: 510: 35.17		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		267114 SRC_MOUSE (3-450): 0: 517: 43.08		DOK2_MOUSE (2-426): 3.13e-118: 354: 31.31
+	Hs
		249714 SRC_HUMAN (3-450): 0: 521: 43.30		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Mm
		362456 ABL1_MOUSE (1-449): 8.87e-171: 510: 35.17		DOK3_MOUSE (1-458): 4.83e-120: 360: 30.90
+	Hs
		249710 FYN_HUMAN (10-450): 0: 520: 42.79		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		249711 YES_HUMAN (10-450): 0: 519: 42.86		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		249709 LCK_HUMAN (3-449): 0: 517: 39.07		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Mm
		267113 ABL1_MOUSE (1-449): 8.87e-171: 510: 35.17		DOK2_MOUSE (2-426): 3.13e-118: 354: 31.31
+	Hs
		249704 ABL1_HUMAN (1-449): 1.85e-170: 510: 35.17		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		160393 LCK_HUMAN (3-449): 0: 517: 39.07		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		440413 FYN_HUMAN (10-450): 0: 520: 42.79		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Dm
		1466645 SRC42_DROME (3-447): 0: 518: 44.15		Q9W3R6_DROME (1-256): 8.51e-59: 206: 25.75
+	Mm
		431363 SRC_MOUSE (3-450): 0: 517: 43.08		FRS2_MOUSE (154-464): 4.47e-56: 196: 21.73
+	Hs
		440159 LCK_HUMAN (3-449): 0: 517: 39.07		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Hs
		220217 HCK_HUMAN (4-449): 7.51e-179: 511: 39.82		FRS3_HUMAN (153-432): 4.02e-52: 185: 20.42