HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	15831486
Identification Methods	pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 535
+	Hs
		249714 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		SRC_HUMAN (1-535): 0: 640: 98.69
+	Hs
		249711 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		YES_HUMAN (1-535): 0: 608: 73.85
+	Hs
		249710 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		FYN_HUMAN (1-535): 0: 594: 68.70
+	Mm
		267115 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		LYN_MOUSE (1-530): 0: 530: 52.35
+	Hs
		557444 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		SRC_HUMAN (1-535): 0: 640: 98.69
+	Mm
		267113 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		ABL1_MOUSE (50-535): 3.66e-169: 510: 40.16
+	Hs
		249709 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		LCK_HUMAN (57-533): 0: 550: 56.79
+	Hs
		463208 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		YES_HUMAN (1-535): 0: 608: 73.85
+	Hs
		249704 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		ABL1_HUMAN (50-535): 3.5e-169: 510: 40.16
+	Hs
		486706 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		FGR_HUMAN (1-534): 0: 581: 65.36
+	Hs
		249725 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		CSK_HUMAN (83-524): 1.15e-171: 494: 39.38
+	Hs
		473465 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		HCK_HUMAN (1-530): 0: 562: 55.66
+	Hs
		249726 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		TXK_HUMAN (11-525): 9.26e-161: 469: 35.06
+	Mm
		683093 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		LYN_MOUSE (1-530): 0: 530: 52.35
+	Hs
		463726 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		LYN_HUMAN (1-530): 0: 531: 52.92
+	Mm
		362440 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		ABL1_MOUSE (50-535): 3.66e-169: 510: 40.16
+	Hs
		840979 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ABL2_HUMAN (2-535): 4.14e-170: 514: 38.46
+	Hs
		362358 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ABL1_HUMAN (50-535): 3.5e-169: 510: 40.16
+	Hs
		840894 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		TEC_HUMAN (62-527): 8.73e-155: 457: 36.00
+	Mm
		666041 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		TEC_MOUSE (87-527): 2.67e-151: 448: 38.22