HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: ABL1 (P00520)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.595

Property	Details
Experiments	12777393
Identification Methods	anti bait coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 1123
+	Hs
		249704 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		ABL1_HUMAN (1-1123): 0: 912: 85.97
+	Mm
		362440 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		ABL1_MOUSE (1-1123): 0: 960: 100.00
+	Hs
		362358 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ABL1_HUMAN (1-1123): 0: 912: 85.97
+	Mm
		267114 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		SRC_MOUSE (32-510): 6.88e-177: 530: 40.04
+	Mm
		267115 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		LYN_MOUSE (9-508): 1.46e-165: 500: 35.77
+	Hs
		249711 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		YES_HUMAN (5-510): 1.36e-178: 535: 39.42
+	Hs
		249714 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		SRC_HUMAN (36-510): 2.96e-178: 534: 40.17
+	Hs
		249710 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		FYN_HUMAN (44-510): 2.15e-175: 527: 40.76
+	Hs
		249709 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		LCK_HUMAN (9-508): 1.28e-172: 519: 38.49
+	Hs
		249726 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		TXK_HUMAN (30-498): 2.34e-169: 511: 36.98
+	Mm
		267116 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		CSK_MOUSE (61-500): 1.23e-150: 459: 37.95
+	Hs
		249725 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		CSK_HUMAN (61-500): 7.24e-151: 460: 37.72
+	Hs
		463208 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		YES_HUMAN (5-510): 1.36e-178: 535: 39.42
+	Hs
		557444 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		SRC_HUMAN (36-510): 2.96e-178: 534: 40.17
+	Hs
		473465 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		HCK_HUMAN (9-508): 1.79e-170: 513: 38.79
+	Hs
		486706 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		FGR_HUMAN (27-509): 9.05e-170: 512: 39.84
+	Mm
		683093 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		LYN_MOUSE (9-508): 1.46e-165: 500: 35.77
+	Hs
		463726 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		LYN_HUMAN (9-508): 4.09e-167: 504: 36.15
+	Mm
		834249 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		CSK_MOUSE (61-500): 1.23e-150: 459: 37.95
+	Mm
		666041 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		TEC_MOUSE (65-498): 4.03e-100: 332: 40.40