HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 543
+	Hs
		249714 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		249710 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		FYN_HUMAN (1-543): 0: 584: 72.16
+	Mm
		267114 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		SRC_MOUSE (1-543): 0: 599: 73.67
+	Hs
		249709 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		463208 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		557444 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		249704 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10
+	Mm
		267115 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		LYN_MOUSE (1-541): 2.87e-180: 519: 53.14
+	Hs
		249726 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		TXK_HUMAN (87-532): 5.4e-166: 483: 37.09
+	Hs
		486706 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		FGR_HUMAN (1-542): 0: 564: 67.10
+	Mm
		267113 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		ABL1_MOUSE (41-543): 7.42e-162: 491: 39.10
+	Hs
		473465 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		HCK_HUMAN (1-541): 0: 545: 57.49
+	Mm
		683093 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		LYN_MOUSE (1-541): 2.87e-180: 519: 53.14
+	Hs
		463726 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Mm
		666041 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		TEC_MOUSE (7-535): 1.44e-169: 495: 33.33
+	Hs
		840979 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96
+	Mm
		362440 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		ABL1_MOUSE (41-543): 7.42e-162: 491: 39.10
+	Hs
		362358 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10
+	Hs
		1065091 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		ITK_HUMAN (7-532): 3.55e-158: 466: 31.54
+	Hs
		840894 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		TEC_HUMAN (7-535): 3.36e-156: 461: 32.78