HitPredict

Interactor 1: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31541095, 34315543
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PX, PDZ~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 803 Hs			1 541
+	Hs
		1122000 ARHG7_HUMAN (1-803): 0: 672: 100.00		SHAN1_HUMAN (43-169): 5.1e-32: 133: 30.71
+	Hs
		1121995 ARHG7_HUMAN (1-803): 0: 672: 100.00		SHAN2_HUMAN (43-147): 5.13e-29: 124: 38.10
+	Hs
		1121951 ARHG7_HUMAN (1-803): 0: 672: 100.00		NHRF2_HUMAN (9-207): 2.41e-25: 108: 21.78
+	Hs
		1121977 ARHG7_HUMAN (1-803): 0: 672: 100.00		SHAN3_HUMAN (44-148): 1.72e-21: 101: 37.14
+	Mm
		1193955 ARHG7_MOUSE (1-792): 0: 587: 91.79		SHAN3_MOUSE (44-148): 2.58e-21: 100: 36.19
+	Hs
		1140192 ARHG6_HUMAN (1-762): 1.38e-166: 503: 53.32		NEB2_HUMAN (40-314): 6.2e-34: 138: 17.98
+	Hs
		1140173 ARHG6_HUMAN (1-762): 1.38e-166: 503: 53.32		NHRF2_HUMAN (9-207): 2.41e-25: 108: 21.78
+	Rn
		237118 ARHG7_RAT (179-761): 8.42e-137: 421: 89.37		SHAN1_RAT (43-183): 3.55e-32: 134: 30.28
+	Rn
		237117 ARHG7_RAT (179-761): 8.42e-137: 421: 89.37		SHAN2_RAT (43-147): 7.54e-29: 124: 38.10
+	Rn
		237116 ARHG7_RAT (179-761): 8.42e-137: 421: 89.37		SHAN3_RAT (44-149): 1.58e-21: 101: 35.85
+	Hs
		584577 VAV_HUMAN (1-754): 1.26e-102: 337: 17.25		NEB2_HUMAN (40-314): 6.2e-34: 138: 17.98
+	Hs
		584588 VAV_HUMAN (1-754): 1.26e-102: 337: 17.25		LIN7C_HUMAN (35-136): 1.32e-27: 111: 34.95
+	Mm
		1193724 SPT13_MOUSE (79-659): 9.31e-107: 343: 18.79		SHAN3_MOUSE (44-148): 2.58e-21: 100: 36.19
+	Hs
		1387016 Q96D37_HUMAN (55-754): 1.93e-84: 287: 15.45		NEB2_HUMAN (40-314): 6.2e-34: 138: 17.98
+	Mm
		60104 KALRN_MOUSE (31-788): 9.7e-70: 253: 15.23		Q7TN74_MOUSE (40-375): 9.11e-39: 153: 14.10
+	Mm
		60091 KALRN_MOUSE (31-788): 9.7e-70: 253: 15.23		SHAN3_MOUSE (44-148): 2.58e-21: 100: 36.19
+	Hs
		1150424 ITSN1_HUMAN (26-244): 4.97e-10: 65.5: 14.63		NHRF2_HUMAN (9-207): 2.41e-25: 108: 21.78
+	Hs
		1154164 ITSN1_HUMAN (26-244): 4.97e-10: 65.5: 14.63		SHAN3_HUMAN (44-148): 1.72e-21: 101: 37.14