HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: ARHG7 (Q9ES28)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)
Gene: Arhgef7

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27507650
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ_6~betaPIX_CC, RhoGEF~SH3_2, SH3_2~SH3_2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 862
+	Hs
		1121977 SHAN3_HUMAN (7-1730): 0: 615: 94.38		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Rn
		237116 SHAN3_RAT (1-1730): 0: 642: 98.10		ARHG7_RAT (158-862): 6.59e-148: 452: 86.67
+	Hs
		1121995 SHAN2_HUMAN (8-1727): 6.42e-134: 462: 41.41		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Mm
		1193724 SHAN3_MOUSE (1-1730): 0: 649: 100.00		SPT13_MOUSE (102-638): 8.46e-93: 308: 20.25
+	Mm
		1193775 SHAN3_MOUSE (1-1730): 0: 649: 100.00		BCR_MOUSE (59-862): 2.36e-80: 284: 13.36
+	Hs
		1154164 SHAN3_HUMAN (7-1730): 0: 615: 94.38		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Mm
		60091 SHAN3_MOUSE (1-1730): 0: 649: 100.00		KALRN_MOUSE (105-632): 1.9e-65: 241: 14.57
+	Rn
		237117 SHAN2_RAT (356-1727): 1.4e-98: 352: 35.53		ARHG7_RAT (158-862): 6.59e-148: 452: 86.67
+	Hs
		1122000 SHAN1_HUMAN (327-1725): 6.72e-26: 119: 13.94		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Hs
		540086 TNKS2_HUMAN (2-557): 1.03e-86: 312: 13.15		BCR_HUMAN (90-862): 1.19e-84: 297: 13.23
+	Hs
		1333064 ANR52_HUMAN (2-375): 9.76e-79: 286: 16.59		ARHG2_HUMAN (96-860): 1.29e-93: 318: 13.04
+	Hs
		177280 ANR28_HUMAN (2-383): 4.19e-78: 284: 15.52		ARHG2_HUMAN (96-860): 1.29e-93: 318: 13.04
+	Hs
		177332 ANR28_HUMAN (2-383): 4.19e-78: 284: 15.52		PKHG1_HUMAN (214-862): 3.7e-85: 299: 19.03
+	Rn
		237118 SHAN1_RAT (371-1725): 8.77e-29: 128: 12.44		ARHG7_RAT (158-862): 6.59e-148: 452: 86.67
+	Hs
		1091481 ANK3_HUMAN (117-358): 5.45e-50: 198: 23.08		FARP1_HUMAN (204-604): 8.56e-91: 311: 22.07
+	Hs
		540008 ANK3_HUMAN (117-358): 5.45e-50: 198: 23.08		BCR_HUMAN (90-862): 1.19e-84: 297: 13.23
+	Hs
		1154121 MIB1_HUMAN (190-655): 1.42e-49: 194: 11.02		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Hs
		1030717 ANK2_HUMAN (212-349): 4.61e-29: 129: 24.64		FARP1_HUMAN (204-604): 8.56e-91: 311: 22.07
+	Hs
		1091388 ANK3_HUMAN (117-358): 5.45e-50: 198: 23.08		TIAM1_HUMAN (217-435): 6.58e-12: 71.6: 26.16
+	Hs
		592932 ANK1_HUMAN (175-1139): 1.02e-45: 184: 11.52		TIAM1_HUMAN (217-435): 6.58e-12: 71.6: 26.16