HitPredict

Interactor 1: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Interactor 2: PDCD4 (Q53EL6)
Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)
Gene: PDCD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	32296183, 25416956, 17353931, 29395067, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DEAD~MA3, Helicase_C~MA3
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 469
+	Mm
		954046 IF4A1_MOUSE (3-407): 1.31e-159: 457: 89.88		PDCD4_MOUSE (1-469): 0: 574: 96.80
+	Hs
		953906 IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88		PDCD4_HUMAN (1-469): 0: 569: 100.00
+	Hs
		807451 IF4A3_HUMAN (3-407): 4.46e-129: 379: 67.65		PDCD4_HUMAN (1-469): 0: 569: 100.00
+	Dm
		1038265 IF4A_DROME (14-407): 0: 510: 73.86		Q9VY91_DROME (49-469): 1.64e-134: 399: 36.77
+	Hs
		216071 IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88		IF4G3_HUMAN (276-440): 3.3e-43: 165: 20.00
+	Hs
		953859 IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88		IF4G1_HUMAN (319-439): 2.64e-36: 144: 24.79
+	Mm
		954049 IF4A1_MOUSE (3-407): 1.31e-159: 457: 89.88		IF4G1_MOUSE (319-439): 1.5e-35: 142: 23.14
+	Hs
		953855 IF4A1_HUMAN (3-407): 1.31e-159: 457: 89.88		IF4G2_HUMAN (319-434): 1.29e-25: 112: 26.05
+	Hs
		216087 IF4A2_HUMAN (1-407): 1.73e-128: 377: 100.00		IF4G3_HUMAN (276-440): 3.3e-43: 165: 20.00
+	Hs
		141435 DDX3X_HUMAN (2-406): 1.08e-126: 382: 29.51		IF4G1_HUMAN (319-439): 2.64e-36: 144: 24.79
+	Hs
		807384 IF4A3_HUMAN (3-407): 4.46e-129: 379: 67.65		IF4G1_HUMAN (319-439): 2.64e-36: 144: 24.79
+	Hs
		1047004 IF4A2_HUMAN (1-407): 1.73e-128: 377: 100.00		IF4G1_HUMAN (319-439): 2.64e-36: 144: 24.79
+	At
		1373664 IF4A3_ARATH (9-407): 9.53e-127: 373: 69.42		IF4G1_ARATH (304-447): 4.05e-37: 146: 23.61
+	Hs
		141417 DDX3X_HUMAN (2-406): 1.08e-126: 382: 29.51		IF4G2_HUMAN (319-434): 1.29e-25: 112: 26.05
+	Hs
		1005671 IF4A2_HUMAN (1-407): 1.73e-128: 377: 100.00		IF4G2_HUMAN (319-434): 1.29e-25: 112: 26.05