HitPredict

Interactor 1: IF4A (Q02748)
Eukaryotic initiation factor 4A (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A)
Gene: eIF4A

Interactor 2: Q9VY91 (Q9VY91)
Programmed cell death protein 4
Gene: Pdcd4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23878722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEAD~MA3, Helicase_C~MA3
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 403 Dm			1 509
+	Mm
		954046 IF4A1_MOUSE (4-403): 3.8e-180: 508: 72.82		PDCD4_MOUSE (1-505): 2.51e-148: 434: 37.95
+	Hs
		1124261 IF4A2_HUMAN (3-403): 1.91e-180: 509: 72.89		PDCD4_HUMAN (1-505): 4.06e-146: 429: 37.75
+	Hs
		953906 IF4A1_HUMAN (4-403): 3.8e-180: 508: 72.82		PDCD4_HUMAN (1-505): 4.06e-146: 429: 37.75
+	Hs
		807451 IF4A3_HUMAN (12-403): 2.64e-128: 377: 67.60		PDCD4_HUMAN (1-505): 4.06e-146: 429: 37.75
+	Hs
		1047004 IF4A2_HUMAN (3-403): 1.91e-180: 509: 72.89		IF4G1_HUMAN (3-475): 2.97e-87: 295: 12.89
+	Hs
		953859 IF4A1_HUMAN (4-403): 3.8e-180: 508: 72.82		IF4G1_HUMAN (3-475): 2.97e-87: 295: 12.89
+	Hs
		216087 IF4A2_HUMAN (3-403): 1.91e-180: 509: 72.89		IF4G3_HUMAN (69-480): 1.66e-84: 287: 15.24
+	Hs
		216071 IF4A1_HUMAN (4-403): 3.8e-180: 508: 72.82		IF4G3_HUMAN (69-480): 1.66e-84: 287: 15.24
+	Hs
		1005671 IF4A2_HUMAN (3-403): 1.91e-180: 509: 72.89		IF4G2_HUMAN (75-502): 2.43e-74: 254: 14.93
+	Hs
		953855 IF4A1_HUMAN (4-403): 3.8e-180: 508: 72.82		IF4G2_HUMAN (75-502): 2.43e-74: 254: 14.93
+	Hs
		141435 DDX3X_HUMAN (2-402): 5.52e-127: 382: 31.68		IF4G1_HUMAN (3-475): 2.97e-87: 295: 12.89
+	Hs
		807384 IF4A3_HUMAN (12-403): 2.64e-128: 377: 67.60		IF4G1_HUMAN (3-475): 2.97e-87: 295: 12.89
+	Dm
		263475 IF4A_DROME (1-403): 2.12e-137: 400: 100.00		O61380_DROME (5-378): 1.26e-75: 261: 11.06
+	Hs
		141417 DDX3X_HUMAN (2-402): 5.52e-127: 382: 31.68		IF4G2_HUMAN (75-502): 2.43e-74: 254: 14.93
+	Hs
		684201 DDX6_HUMAN (30-399): 2.6e-95: 295: 41.24		IF4G1_HUMAN (3-475): 2.97e-87: 295: 12.89
+	Hs
		216056 DDX6_HUMAN (30-399): 2.6e-95: 295: 41.24		IF4G3_HUMAN (69-480): 1.66e-84: 287: 15.24
+	Mm
		954049 IF4A1_MOUSE (4-403): 3.8e-180: 508: 72.82		IF4G1_MOUSE (359-476): 5.73e-11: 67.3: 23.73
+	At
		1373664 IF4A3_ARATH (6-403): 3.3e-127: 374: 66.08		IF4G1_ARATH (354-483): 2.56e-29: 124: 31.54