HitPredict

Interactor 1: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Interactor 2: IF4G1 (Q04637)
Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)
Gene: EIF4G1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 9418880, 24768540, 27864334, 16648488, 16541103, 24248602, 38334954, 31839598, 28514442, 17353931, 29395067, 33961781, 35235311, 37071682, 17053147, 22586265, 18606994, 23478064, unassigned3799, 19203580 and 3 others

more...
Identification Methods affinity chromatography technology, cross-linking study, proximity labelling technology, dynamic light scattering, molecular sieving, isothermal titration calorimetry, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, surface plasmon resonance, nuclear magnetic resonance and 2 others

more...
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~MA3, DEAD~MIF4G, Helicase_C~MA3, Helicase_C~MIF4G
Common GO terms GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 406
Hs

1 1599
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Dm
+ Dm
+ Sc
+ Hs
+ Sc
+ Hs
+ Mm
+ Sc
+ Hs
+ Hs
+ Hs
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025