Protein: ARHGG
Rho guanine nucleotide exchange factor 16 (Ephexin-4)

Gene: ARHGG, ARHGEF16
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q5VV41

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0030165 - PDZ domain binding
GO:0030971 - receptor tyrosine kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091515

DLG1
Disks large homolog 1

3

9

High-throughput

0.827

High

955281

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.754

High

1218385

TFG
Protein TFG

1

8

High-throughput

0.740

High

987069

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

6

High-throughput

0.737

High

1104832

SNTB2
Beta-2-syntrophin

2

13

High-throughput

0.737

High

1218376

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

2

15

High-throughput

0.737

High

1218395

ANFY1
Rabankyrin-5

2

9

High-throughput

0.737

High

691109

1433T
14-3-3 protein theta

4

20

High-throughput

0.697

High

966449

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

835690

KPCI
Protein kinase C iota type

1

11

High-throughput

0.691

High

990334

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.683

High

1049400

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

1149087

SF3A1
Splicing factor 3A subunit 1

2

6

High-throughput

0.659

High

729927

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.650

High

728288

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.647

High

1122253

SCRIB
Protein scribble homolog

3

12

High-throughput

0.641

High

714185

PML
Protein PML

2

6

High-throughput

0.628

High

1218389

IF122
Intraflagellar transport protein 122 homolog

2

6

High-throughput

0.628

High

374671

RASH
GTPase HRas

1

11

High-throughput

0.618

High

710295

EPHA2
Ephrin type-A receptor 2

1

20

Small-scale

0.618

High

978074

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1218373

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.618

High

1218383

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.618

High

730660

1433S
14-3-3 protein sigma

2

20

High-throughput

0.612

High

729302

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

4

High-throughput

0.606

High

1133100

LASP1
LIM and SH3 domain protein 1

2

9

High-throughput

0.606

High

1218398

MAGD1
Melanoma-associated antigen D1

2

1

High-throughput

0.606

High

1218375

DPP8
Dipeptidyl peptidase 8

2

0

High-throughput

0.602

High

1218388

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.602

High

1053230

Q05BK6
TFG protein

1

2

High-throughput

0.594

High

167517

TX1B3
Tax1-binding protein 3

1

20

Small-scale

0.573

High

1153044

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

3

High-throughput

0.571

High

1218397

E41L3
Band 4.1-like protein 3

2

10

High-throughput

0.571

High

1119821

CKAP5
Cytoskeleton-associated protein 5

1

3

Small-scale

0.561

High

156290

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

1

High-throughput

0.536

High

537319

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.536

High

1218379

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

4

High-throughput

0.523

High

522440

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

1

High-throughput

0.521

High

760936

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

2

High-throughput

0.521

High

869890

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

1

High-throughput

0.521

High

1204971

RABL3
Rab-like protein 3

2

19

High-throughput

0.521

High

1218377

MGAP
MAX gene-associated protein

2

1

High-throughput

0.521

High

971627

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.515

High

288856

LYPA1
Acyl-protein thioesterase 1

1

0

High-throughput

0.513

High

385831

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

High-throughput

0.481

High

1218381

LNX1
E3 ubiquitin-protein ligase LNX

1

17

Small-scale

0.481

High

172922

XPO1
Exportin-1

1

6

High-throughput

0.479

High

556143

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

656152

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

6

High-throughput

0.479

High

701840

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.479

High

731384

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

862658

UTRN
Utrophin

1

11

High-throughput

0.479

High

904827

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

910938

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.479

High

1151420

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

1

High-throughput

0.479

High

1152101

MARE1
Microtubule-associated protein RP/EB family member 1

1

4

High-throughput

0.479

High

1218382

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

7

High-throughput

0.479

High

1218390

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.479

High

1218394

HACD3
Very-long-chain

1

1

High-throughput

0.479

High

1218396

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1218378

BOLL
Protein boule-like

1

2

High-throughput

0.470

High

1218384

ELMO1
Engulfment and cell motility protein 1

1

0

Small-scale

0.458

High

161046

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

8

Small-scale

0.457

High

211339

RFOX2
RNA binding protein fox-1 homolog 2

1

4

High-throughput

0.437

High

228281

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.437

High

424419

HMGN1
Non-histone chromosomal protein HMG-14

1

4

High-throughput

0.437

High

471078

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.437

High

472810

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.437

High

588898

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

666307

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.437

High

1131732

LBR
Delta(14)-sterol reductase LBR

1

2

High-throughput

0.437

High

1217135

RIF1
Telomere-associated protein RIF1

1

9

High-throughput

0.437

High

1218386

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.437

High

1218392

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.437

High

1218393

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

3

High-throughput

0.437

High

1198430

CEP55
Centrosomal protein of 55 kDa

1

1

High-throughput

0.417

High

899659

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

2

0

High-throughput

0.328

High

1218380

COQ8A
Atypical kinase COQ8A, mitochondrial

2

0

High-throughput

0.298

High

1218387

RM53
Large ribosomal subunit protein mL53

2

0

High-throughput

0.298

High

1218391

TM160
Transmembrane protein 160

1

0

High-throughput

0.279

Low

1218374

RL22L
Ribosomal protein eL22-like

1

0

High-throughput

0.249

Low

1218399

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.249

Low

1212400

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025