HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: PHLB3 (Q6NSJ2)
Pleckstrin homology-like domain family B member 3
Gene: PHLDB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 640
+	Hs
		412098 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		PHLB3_HUMAN (1-640): 4.07e-106: 336: 100.00
+	Hs
		710307 EPHA2_HUMAN (148-822): 2.67e-146: 457: 22.71		PHLB3_HUMAN (1-640): 4.07e-106: 336: 100.00
+	Hs
		412189 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		PHLB1_HUMAN (51-636): 3.9e-62: 226: 27.10
+	Hs
		710337 EPHA2_HUMAN (148-822): 2.67e-146: 457: 22.71		PHLB2_HUMAN (44-636): 4.47e-74: 260: 25.87
+	Hs
		412200 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		MTMRD_HUMAN (410-635): 1.92e-44: 173: 21.77
+	Hs
		710339 EPHA2_HUMAN (148-822): 2.67e-146: 457: 22.71		PHLB1_HUMAN (51-636): 3.9e-62: 226: 27.10
+	Hs
		331695 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		MTMR5_HUMAN (399-632): 4.94e-37: 150: 19.78
+	Hs
		411474 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45
+	Hs
		411919 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		DCTN1_HUMAN (2-464): 1.02e-34: 143: 14.99
+	Hs
		331702 FGFR1_HUMAN (183-821): 2.54e-164: 499: 23.88		MTMR5_HUMAN (399-632): 4.94e-37: 150: 19.78
+	Hs
		710604 EPHA3_HUMAN (82-820): 1.93e-161: 496: 21.34		MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45
+	Hs
		331715 EPHA2_HUMAN (148-822): 2.67e-146: 457: 22.71		MTMR5_HUMAN (399-632): 4.94e-37: 150: 19.78
+	Hs
		411300 NTRK1_HUMAN (4-822): 1.62e-172: 519: 45.86		DESP_HUMAN (66-484): 4.27e-09: 62: 13.26
+	Hs
		1062968 DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37		DCTN1_HUMAN (2-464): 1.02e-34: 143: 14.99
+	Hs
		773080 ALK_HUMAN (513-799): 4.98e-64: 236: 41.44		MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45
+	Hs
		225465 INSR_HUMAN (513-809): 2.12e-70: 254: 43.38		CYH3_HUMAN (532-630): 1.48e-22: 102: 26.96
+	Hs
		648572 FGFR4_HUMAN (188-416): 1.23e-09: 63.9: 13.85		PHLB1_HUMAN (51-636): 3.9e-62: 226: 27.10