HitPredict

Interactor 1: CCL24 (O00175)
C-C motif chemokine 24 (CK-beta-6) (Eosinophil chemotactic protein 2) (Eotaxin-2) (Myeloid progenitor inhibitory factor 2) (MPIF-2) (Small-inducible cytokine A24)
Gene: CCL24

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	10733106, 12218106
Identification Methods	experimental interaction detection, monoclonal antibody blockade
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0001938 - positive regulation of endothelial cell proliferation GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0006955 - immune response GO:0045766 - positive regulation of angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 119 Hs			1 355
+	Hs
		686635 CCL8_HUMAN (16-98): 2.21e-33: 113: 36.15		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		686636 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		945622 CCL8_HUMAN (16-98): 2.21e-33: 113: 36.15		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Mm
		486358 CCL2_MOUSE (3-98): 3.92e-34: 117: 38.54		CCR2_MOUSE (4-355): 8.41e-83: 257: 51.41
+	Hs
		945630 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Hs
		849614 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783815 CCL8_HUMAN (16-98): 2.21e-33: 113: 36.15		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		849619 CCL13_HUMAN (5-97): 4.23e-31: 107: 35.71		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783816 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		783833 CCL13_HUMAN (5-97): 4.23e-31: 107: 35.71		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		849647 CCL8_HUMAN (16-98): 2.21e-33: 113: 36.15		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		849648 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Mm
		192790 CCL2_MOUSE (3-98): 3.92e-34: 117: 38.54		CCRL2_MOUSE (44-318): 3.48e-55: 186: 38.79
+	Hs
		134373 CCL8_HUMAN (16-98): 2.21e-33: 113: 36.15		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134374 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134400 CCL13_HUMAN (5-97): 4.23e-31: 107: 35.71		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Mm
		139696 CCL2_MOUSE (3-98): 3.92e-34: 117: 38.54		ACKR2_MOUSE (16-343): 1.57e-46: 164: 34.55
+	Mm
		291526 CCL11_MOUSE (6-98): 6.8e-31: 107: 31.18		CXCR3_MOUSE (36-318): 4.07e-45: 160: 36.36
+	Hs
		830622 CCL7_HUMAN (16-97): 5.11e-32: 110: 34.15		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		830629 CCL13_HUMAN (5-97): 4.23e-31: 107: 35.71		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36