HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: Q7TN74 (Q7TN74)
Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)
Gene: Ppp1r9a

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SAM_2, PDZ~PDZ_6, PDZ~SAM_1, SAM_1~SAM_2, PDZ~SH3_2
Common GO terms	GO:0003779 - actin binding GO:0043197 - dendritic spine GO:0050804 - modulation of chemical synaptic transmission
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 1095
+	Mm
		1193811 SHAN3_MOUSE (1-1730): 0: 649: 100.00		DLG1_MOUSE (240-1035): 6.88e-59: 221: 12.18
+	Mm
		1193754 SHAN3_MOUSE (1-1730): 0: 649: 100.00		DLG4_MOUSE (363-1033): 2.13e-56: 211: 12.40
+	Mm
		1193783 SHAN3_MOUSE (1-1730): 0: 649: 100.00		NEB2_MOUSE (1-827): 1.65e-48: 188: 44.91
+	Hs
		1402513 SHAN3_HUMAN (7-1730): 0: 615: 94.38		NEB2_HUMAN (1-827): 2.41e-48: 187: 45.26
+	Mm
		1193879 SHAN3_MOUSE (1-1730): 0: 649: 100.00		DLG2_MOUSE (400-609): 1.83e-30: 131: 21.03
+	Hs
		177331 ANR28_HUMAN (2-383): 4.19e-78: 284: 15.52		NEB1_HUMAN (1-1094): 2.47e-123: 407: 90.22
+	Hs
		1006123 SHAN2_HUMAN (8-1727): 6.42e-134: 462: 41.41		DLG4_HUMAN (363-1033): 2.1e-55: 207: 11.78
+	Mm
		1223602 SHAN2_MOUSE (356-1727): 3.12e-100: 357: 35.35		DLG4_MOUSE (363-1033): 2.13e-56: 211: 12.40
+	Mm
		1247105 SHAN2_MOUSE (356-1727): 3.12e-100: 357: 35.35		NEB2_MOUSE (1-827): 1.65e-48: 188: 44.91
+	Dm
		118901 Q7KU92_DROME (50-1023): 7.37e-81: 299: 12.36		M9NFI9_DROME (451-912): 4.55e-43: 174: 38.53
+	Hs
		177298 ANR28_HUMAN (2-383): 4.19e-78: 284: 15.52		NEB2_HUMAN (1-827): 2.41e-48: 187: 45.26
+	Mm
		1283095 SHAN2_MOUSE (356-1727): 3.12e-100: 357: 35.35		GRIP1_MOUSE (349-591): 1.96e-14: 80.5: 14.82
+	Dm
		119053 TNKS_DROME (1-271): 1.64e-59: 227: 17.29		M9NFI9_DROME (451-912): 4.55e-43: 174: 38.53
+	Hs
		299788 TNKS2_HUMAN (2-557): 1.03e-86: 312: 13.15		MPDZ_HUMAN (508-755): 1.07e-13: 78.1: 17.27
+	Hs
		1365592 TNKS2_HUMAN (2-557): 1.03e-86: 312: 13.15		MY18A_HUMAN (591-1094): 4.95e-11: 69.4: 13.75
+	Mm
		109264 ANK3_MOUSE (224-771): 4.92e-39: 162: 11.99		DLG4_MOUSE (363-1033): 2.13e-56: 211: 12.40
+	Mm
		1223601 DAPK1_MOUSE (2-202): 8.93e-38: 157: 17.16		DLG4_MOUSE (363-1033): 2.13e-56: 211: 12.40
+	Mm
		109266 ANK3_MOUSE (224-771): 4.92e-39: 162: 11.99		NEB2_MOUSE (1-827): 1.65e-48: 188: 44.91
+	Hs
		299723 TNKS1_HUMAN (1-272): 1.43e-59: 228: 15.54		MPDZ_HUMAN (508-755): 1.07e-13: 78.1: 17.27
+	Hs
		1090156 MIB1_HUMAN (190-655): 1.42e-49: 194: 11.02		PTN13_HUMAN (327-763): 2.42e-18: 93.6: 13.94