HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: LZTR1 (Q8N653)
Leucine-zipper-like transcriptional regulator 1 (LZTR-1)
Gene: LZTR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37626065
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BACK~BTB, BACK~Kelch_1, BTB~BTB, Kelch_1~Kelch_1
Common GO terms	GO:0031463 - Cul3-RING ubiquitin ligase complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 840
+	Hs
		1199050 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KLHL3_HUMAN (613-837): 8.11e-54: 199: 22.22
+	Hs
		1198978 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KLH12_HUMAN (4-295): 7.87e-52: 192: 18.31
+	Hs
		1199056 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KLH20_HUMAN (7-237): 8.71e-41: 161: 19.05
+	Hs
		1199045 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KLHL9_HUMAN (187-519): 2.48e-39: 157: 14.24
+	Hs
		1199046 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KLH13_HUMAN (187-517): 4.39e-39: 156: 14.04
+	Hs
		1247782 KLH17_HUMAN (11-566): 6.8e-157: 465: 40.68		KLHL3_HUMAN (613-837): 8.11e-54: 199: 22.22
+	Dm
		1047172 KELC_DROME (9-567): 1.88e-154: 481: 40.39		KELC_DROME (187-476): 1.72e-45: 179: 14.33
+	Hs
		1121551 KEAP1_HUMAN (8-564): 5.21e-156: 461: 35.88		KLHL3_HUMAN (613-837): 8.11e-54: 199: 22.22
+	Hs
		1198983 KLH17_HUMAN (11-566): 6.8e-157: 465: 40.68		KLH12_HUMAN (4-295): 7.87e-52: 192: 18.31
+	Hs
		1490827 KLH20_HUMAN (2-566): 1.29e-168: 493: 43.94		KLH20_HUMAN (7-237): 8.71e-41: 161: 19.05
+	Dm
		1486948 KLHDB_DROME (3-566): 4.09e-165: 485: 42.40		KLHDB_DROME (237-525): 1.53e-42: 166: 13.75
+	Hs
		1454626 KLH20_HUMAN (2-566): 1.29e-168: 493: 43.94		KLHL9_HUMAN (187-519): 2.48e-39: 157: 14.24
+	Hs
		329071 KLHL2_HUMAN (13-567): 6.07e-155: 458: 41.36		KLH12_HUMAN (4-295): 7.87e-52: 192: 18.31
+	Hs
		1121411 KLH12_HUMAN (1-568): 7.94e-179: 518: 100.00		KEAP1_HUMAN (345-571): 6.16e-12: 71.1: 8.19
+	Hs
		1490837 KLH20_HUMAN (2-566): 1.29e-168: 493: 43.94		NS1BP_HUMAN (336-525): 8.77e-16: 83.8: 10.42
+	Mm
		1491930 KEAP1_MOUSE (8-564): 3.8e-156: 462: 35.52		KEAP1_MOUSE (334-583): 4e-12: 71.9: 7.84
+	Hs
		1121393 KEAP1_HUMAN (8-564): 5.21e-156: 461: 35.88		KEAP1_HUMAN (345-571): 6.16e-12: 71.1: 8.19
+	Hs
		329061 KLHL2_HUMAN (13-567): 6.07e-155: 458: 41.36		KEAP1_HUMAN (345-571): 6.16e-12: 71.1: 8.19