HitPredict

Interactor 1: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1732 Hs			1 779
+	Hs
		1434353 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		157849 CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		728622 AKT2_HUMAN (13-391): 2.77e-129: 414: 30.65		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		728428 AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		1144311 STK38_HUMAN (66-404): 1.25e-89: 302: 45.07		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		287729 KS6A5_HUMAN (60-334): 2.61e-72: 261: 27.46		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		157495 CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42		CYTSA_HUMAN (176-644): 5.29e-44: 173: 10.59
+	Hs
		157020 CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42		MYH9_HUMAN (136-643): 3.16e-39: 159: 11.86
+	Hs
		157526 CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42		MPRIP_HUMAN (2-488): 4.24e-39: 158: 15.95
+	Hs
		728066 AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02		MYH9_HUMAN (136-643): 3.16e-39: 159: 11.86
+	Hs
		270846 ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87		PKHA4_HUMAN (1-779): 1.18e-148: 455: 100.00
+	Hs
		158009 CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42		PKHA6_HUMAN (287-614): 3.87e-24: 111: 19.28
+	Hs
		773091 ST38L_HUMAN (10-417): 2.89e-126: 405: 38.06		MYH9_HUMAN (136-643): 3.16e-39: 159: 11.86
+	Hs
		728218 AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02		GAB1_HUMAN (52-668): 9.24e-36: 146: 10.87
+	Hs
		1437919 LATS2_HUMAN (65-376): 3.55e-75: 275: 41.23		PKHA1_HUMAN (3-261): 4.01e-41: 157: 17.49
+	Hs
		1437670 LATS2_HUMAN (65-376): 3.55e-75: 275: 41.23		PKHA5_HUMAN (114-732): 4.97e-38: 154: 17.22
+	Hs
		1234975 LATS2_HUMAN (65-376): 3.55e-75: 275: 41.23		PKHA7_HUMAN (153-638): 3.81e-34: 143: 23.37
+	Hs
		772782 ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77		MYH9_HUMAN (136-643): 3.16e-39: 159: 11.86
+	Hs
		270816 ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87		RHG21_HUMAN (12-723): 2.27e-35: 147: 13.40
+	Hs
		1106260 ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77		GAB1_HUMAN (52-668): 9.24e-36: 146: 10.87