HitPredict

Interactor 1: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27173435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 923 Hs			1 676
+	Hs
		872642 EPHA4_HUMAN (206-912): 6.5e-164: 506: 14.77		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665596 EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		872436 EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665234 EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1153279 KSR1_HUMAN (1-923): 0: 765: 100.00		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		411709 LCK_HUMAN (591-890): 2.14e-99: 322: 24.59		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1217987 KSR1_HUMAN (1-923): 0: 765: 100.00		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		1197808 KSR1_HUMAN (1-923): 0: 765: 100.00		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		872712 EPHA4_HUMAN (206-912): 6.5e-164: 506: 14.77		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		665662 EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		872492 EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		1072603 EPHA7_HUMAN (215-914): 9.83e-149: 467: 14.59		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		411764 LCK_HUMAN (591-890): 2.14e-99: 322: 24.59		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		665661 EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		872491 EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		1072602 EPHA7_HUMAN (215-914): 9.83e-149: 467: 14.59		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		665267 EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62		PHLB3_HUMAN (9-121): 9.24e-25: 111: 28.07
+	Hs
		600673 EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		411861 LCK_HUMAN (591-890): 2.14e-99: 322: 24.59		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		411765 LCK_HUMAN (591-890): 2.14e-99: 322: 24.59		PHLB3_HUMAN (9-121): 9.24e-25: 111: 28.07