HitPredict

Interactor 1: MYOME (Q5VU43)
Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)
Gene: PDE4DIP

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2346 Hs			1 2541
+	Hs
		1134778 NUMA1_HUMAN (1-1306): 3.35e-47: 189: 11.77		TLN1_HUMAN (1-2541): 0: 1185: 100.00
+	Mm
		683940 MYOME_MOUSE (1-2346): 1.06e-159: 550: 66.87		EZRI_MOUSE (84-708): 5.8e-82: 284: 13.53
+	Hs
		1143153 MYOME_HUMAN (1-2346): 0: 679: 100.00		PLEC_HUMAN (916-2528): 1.86e-24: 115: 11.40
+	Mm
		683961 MYOME_MOUSE (1-2346): 1.06e-159: 550: 66.87		RADI_MOUSE (163-404): 1.93e-56: 210: 22.27
+	Mm
		683948 MYOME_MOUSE (1-2346): 1.06e-159: 550: 66.87		MOES_MOUSE (163-404): 2.52e-51: 194: 23.05
+	Mm
		1283060 MYOME_MOUSE (1-2346): 1.06e-159: 550: 66.87		MACF1_MOUSE (602-2503): 4.56e-17: 91.1: 8.97
+	Hs
		1134723 NUMA1_HUMAN (1-1306): 3.35e-47: 189: 11.77		E41L1_HUMAN (16-610): 1.4e-103: 357: 12.54
+	Hs
		1433661 MYH4_HUMAN (1265-2339): 3.03e-31: 137: 10.00		E41L1_HUMAN (16-610): 1.4e-103: 357: 12.54
+	Hs
		582796 GOGB1_HUMAN (688-2333): 9.17e-42: 172: 11.44		EZRI_HUMAN (84-666): 3.04e-82: 285: 14.65
+	Hs
		683840 GOGB1_HUMAN (688-2333): 9.17e-42: 172: 11.44		MOES_HUMAN (163-404): 1.94e-51: 195: 23.05
+	Hs
		767401 CENPF_HUMAN (901-2161): 3.62e-35: 150: 9.01		RADI_HUMAN (163-404): 6.21e-57: 211: 22.27
+	Hs
		1132256 GOGB1_HUMAN (688-2333): 9.17e-42: 172: 11.44		GOGB1_HUMAN (243-2541): 1.91e-45: 184: 8.51
+	Hs
		1134767 NUMA1_HUMAN (1-1306): 3.35e-47: 189: 11.77		MACF1_HUMAN (492-2519): 1.06e-24: 116: 8.53
+	Dm
		1404010 MYSN_DROME (403-1455): 2.68e-32: 140: 12.23		MYO7A_DROME (19-503): 4.98e-26: 120: 15.46
+	Hs
		563081 MYH8_HUMAN (1265-2328): 3.06e-32: 140: 10.80		MYH4_HUMAN (1762-2538): 2.39e-20: 101: 9.21
+	Mm
		563088 MYH8_MOUSE (1279-2339): 5.87e-33: 143: 9.72		MYH6_MOUSE (1882-2532): 1.06e-14: 83: 10.30
+	Hs
		556973 MYH4_HUMAN (1265-2339): 3.03e-31: 137: 10.00		MYH7_HUMAN (1889-2532): 5.43e-16: 87.2: 10.32
+	Hs
		562992 MYH6_HUMAN (1279-2312): 4.48e-30: 133: 9.72		MYH6_HUMAN (1882-2532): 1.01e-14: 83: 10.61
+	Hs
		563078 MYH8_HUMAN (1265-2328): 3.06e-32: 140: 10.80		MYH13_HUMAN (503-1573): 1.8e-11: 72.5: 9.16