HitPredict

Interactor 1: TRI68 (Q6AZZ1)
E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)
Gene: TRIM68

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	zf-B_box~zf-RING_UBOX
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0045087 - innate immune response GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 485 Hs			1 237
+	Hs
		1382344 TRI39_HUMAN (7-485): 1.8e-144: 425: 35.34		RN166_HUMAN (1-237): 7.87e-65: 202: 100.00
+	Hs
		623482 RO52_HUMAN (1-482): 3.2e-159: 461: 42.53		RN125_HUMAN (6-236): 4.42e-42: 144: 30.67
+	Hs
		623089 RO52_HUMAN (1-482): 3.2e-159: 461: 42.53		RO52_HUMAN (19-166): 2.09e-31: 121: 20.95
+	Hs
		1231166 TRI68_HUMAN (1-485): 2.22e-162: 470: 100.00		TRI68_HUMAN (20-175): 5.26e-27: 109: 16.67
+	Hs
		623523 RO52_HUMAN (1-482): 3.2e-159: 461: 42.53		TRIM6_HUMAN (21-178): 7.75e-27: 109: 15.85
+	Hs
		623522 RO52_HUMAN (1-482): 3.2e-159: 461: 42.53		TRI31_HUMAN (19-180): 1.06e-25: 105: 15.85
+	Hs
		623524 RO52_HUMAN (1-482): 3.2e-159: 461: 42.53		TRIM5_HUMAN (21-166): 3.32e-25: 104: 20.53
+	Mm
		1189942 RO52_MOUSE (3-482): 4.29e-148: 433: 38.54		Q3U7K7_MOUSE (22-165): 1.52e-30: 119: 18.75
+	Hs
		623551 TRI39_HUMAN (7-485): 1.8e-144: 425: 35.34		RO52_HUMAN (19-166): 2.09e-31: 121: 20.95
+	Hs
		136659 TRI27_HUMAN (1-485): 2.5e-139: 412: 34.77		TRAF5_HUMAN (12-237): 6.39e-31: 121: 21.21
+	Hs
		571869 TRI27_HUMAN (1-485): 2.5e-139: 412: 34.77		RO52_HUMAN (19-166): 2.09e-31: 121: 20.95
+	Hs
		1439329 TRI39_HUMAN (7-485): 1.8e-144: 425: 35.34		TRI17_HUMAN (25-167): 1.39e-24: 103: 18.83
+	Hs
		572178 TRI27_HUMAN (1-485): 2.5e-139: 412: 34.77		TRAF4_HUMAN (17-212): 3.61e-29: 115: 18.50
+	Hs
		572193 TRI27_HUMAN (1-485): 2.5e-139: 412: 34.77		TRI31_HUMAN (19-180): 1.06e-25: 105: 15.85
+	Hs
		572115 TRI27_HUMAN (1-485): 2.5e-139: 412: 34.77		TRI43_HUMAN (20-169): 5.41e-25: 103: 16.03
+	Hs
		1390312 TRI11_HUMAN (1-483): 5.34e-140: 412: 41.20		TRI10_HUMAN (19-180): 2.53e-24: 102: 17.86
+	Hs
		1420568 TRIM6_HUMAN (3-483): 1.38e-131: 391: 36.78		TRIM6_HUMAN (21-178): 7.75e-27: 109: 15.85
+	Hs
		1420569 TRIM6_HUMAN (3-483): 1.38e-131: 391: 36.78		TRIM5_HUMAN (21-166): 3.32e-25: 104: 20.53