HitPredict

Interactor 1: PHLB3 (Q6NSJ2)
Pleckstrin homology-like domain family B member 3
Gene: PHLDB3

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 640 Hs			1 720
+	Hs
		225488 CYH3_HUMAN (532-630): 1.48e-22: 102: 26.96		CNKR1_HUMAN (1-720): 0: 554: 100.00
+	Hs
		1237901 PHLB3_HUMAN (1-640): 4.07e-106: 336: 100.00		SKAP1_HUMAN (398-546): 2.02e-21: 98.4: 22.22
+	Hs
		772748 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		SPTB2_HUMAN (12-538): 2.48e-78: 276: 14.91
+	Hs
		1028766 DCTN1_HUMAN (2-464): 1.02e-34: 143: 14.99		SPTB2_HUMAN (12-538): 2.48e-78: 276: 14.91
+	Mm
		1253393 TAOK2_MOUSE (69-543): 3.53e-40: 160: 17.14		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Hs
		174713 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		SPTN2_HUMAN (12-552): 8.02e-51: 194: 13.83
+	Hs
		1123824 DCTN1_HUMAN (2-464): 1.02e-34: 143: 14.99		PKHA5_HUMAN (329-717): 2.1e-47: 183: 15.74
+	Mm
		148524 CYH3_MOUSE (532-630): 3.89e-24: 107: 27.19		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Hs
		772858 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		PKHA7_HUMAN (321-714): 8.46e-41: 162: 15.19
+	Hs
		225479 CYH3_HUMAN (532-630): 1.48e-22: 102: 26.96		CYH1_HUMAN (142-521): 2.85e-52: 187: 12.56
+	Hs
		776857 MYH11_HUMAN (8-493): 3.71e-37: 151: 11.29		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40
+	Hs
		773022 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40
+	Hs
		1123816 DCTN1_HUMAN (2-464): 1.02e-34: 143: 14.99		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40
+	Hs
		331773 MTMR5_HUMAN (399-632): 4.94e-37: 150: 19.78		SKAP1_HUMAN (398-546): 2.02e-21: 98.4: 22.22
+	Hs
		587699 DESP_HUMAN (66-484): 4.27e-09: 62: 13.26		PKHA7_HUMAN (321-714): 8.46e-41: 162: 15.19
+	Hs
		772900 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		RHG24_HUMAN (402-535): 1.86e-13: 76.1: 19.31
+	Hs
		225486 CYH3_HUMAN (532-630): 1.48e-22: 102: 26.96		ICEF1_HUMAN (569-704): 3.3e-25: 111: 32.35
+	Hs
		772903 MYH9_HUMAN (8-493): 2.63e-35: 145: 9.45		AFAP1_HUMAN (379-494): 3.04e-09: 62.3: 19.17
+	Hs
		587805 DESP_HUMAN (66-484): 4.27e-09: 62: 13.26		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40