HitPredict

Interactor 1: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Interactor 2: LEF1 (Q9UJU2)
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
Gene: LEF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	16714285, 27195665
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 399
+	Hs
		1261302 RN138_HUMAN (1-245): 6.92e-57: 183: 100.00		TF7L2_HUMAN (22-387): 1.66e-58: 202: 51.88
+	Hs
		585039 RO52_HUMAN (6-157): 6.92e-32: 123: 17.11		CIC_HUMAN (63-393): 8.23e-35: 138: 16.47
+	Hs
		1223389 TRI22_HUMAN (11-171): 1.31e-29: 117: 14.97		CIC_HUMAN (63-393): 8.23e-35: 138: 16.47
+	Hs
		817987 TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Hs
		233834 TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64		HBP1_HUMAN (174-369): 5.84e-31: 125: 20.87
+	Hs
		1300908 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		CIC_HUMAN (63-393): 8.23e-35: 138: 16.47
+	Mm
		818761 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		SOX2_MOUSE (261-396): 3.98e-36: 136: 21.32
+	Hs
		1313366 TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14		HM20A_HUMAN (202-387): 3.6e-33: 128: 15.34
+	Hs
		818385 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Mm
		1321738 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		HM20A_MOUSE (202-387): 1.02e-31: 125: 13.76
+	Hs
		818546 KCMF1_HUMAN (147-236): 1.38e-25: 105: 32.22		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Hs
		988011 RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40		CIC_HUMAN (63-393): 8.23e-35: 138: 16.47
+	Mm
		1321748 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		HM20B_MOUSE (245-396): 5.3e-29: 117: 16.56
+	Hs
		727853 RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40		SOX6_HUMAN (287-369): 2.63e-23: 104: 30.12