HitPredict

Interactor 1: Q7KA43 (Q7KA43)
Anaphase-promoting complex subunit 11 (Cyclosome subunit 11)
Gene: lmgA

Interactor 2: Q9W1E5 (Q9W1E5)
Anaphase-promoting complex subunit 2
Gene: mr

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	22417125, 22491092, 37061542, unassigned1513
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ANAPC2~zf-ANAPC11, Cullin~zf-ANAPC11
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005680 - anaphase-promoting complex GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 85 Dm			1 802
+	Hs
		983791 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL1_HUMAN (94-794): 0: 597: 13.03
+	Mm
		984057 RBX1_MOUSE (2-82): 4.31e-28: 99: 36.05		CUL1_MOUSE (94-794): 0: 597: 13.03
+	Dm
		1173437 RBX1A_DROME (2-82): 9.36e-28: 98.3: 36.05		CUL1_DROME (85-794): 0: 564: 13.17
+	Hs
		1452595 APC11_HUMAN (1-82): 1.61e-28: 99.4: 73.17		ANC2_HUMAN (58-802): 0: 558: 36.72
+	Hs
		983792 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL2_HUMAN (88-784): 0: 550: 10.56
+	Hs
		983794 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL4A_HUMAN (123-790): 0: 540: 13.24
+	Hs
		983793 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL3_HUMAN (103-791): 4.63e-180: 537: 12.04
+	Dm
		1203000 RBX1A_DROME (2-82): 9.36e-28: 98.3: 36.05		Q5BI50_DROME (98-790): 1.07e-178: 535: 13.28
+	Mm
		984047 RBX1_MOUSE (2-82): 4.31e-28: 99: 36.05		CUL4A_MOUSE (123-790): 2.85e-178: 532: 13.10
+	Hs
		983795 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL4B_HUMAN (86-790): 2.18e-174: 527: 12.42
+	Mm
		58988 RBX1_MOUSE (2-82): 4.31e-28: 99: 36.05		CUL4B_MOUSE (86-790): 1.67e-173: 526: 12.28
+	Dm
		1304398 RBX1A_DROME (2-82): 9.36e-28: 98.3: 36.05		Q8IP45_DROME (104-791): 1.01e-172: 523: 13.39
+	At
		1300979 APC11_ARATH (1-82): 1.48e-30: 104: 60.98		APC2_ARATH (58-802): 4.14e-171: 517: 28.73
+	Ce
		1164796 RBX1_CAEEL (2-82): 1.35e-27: 97.9: 36.05		CUL2_CAEEL (87-793): 2.41e-167: 505: 9.10
+	Dm
		1466835 RBX1A_DROME (2-82): 9.36e-28: 98.3: 36.05		Q9V9R2_DROME (88-790): 1.5e-167: 504: 10.41
+	Sp
		151340 RBX1_SCHPO (2-82): 5.88e-28: 98.6: 38.37		CUL1_SCHPO (117-789): 5.12e-167: 503: 13.67
+	Hs
		1371883 APC11_HUMAN (1-82): 1.61e-28: 99.4: 73.17		CUL5_HUMAN (94-788): 7.12e-154: 470: 11.38
+	Hs
		983919 RBX1_HUMAN (2-82): 4.31e-28: 99: 36.05		CUL5_HUMAN (94-788): 7.12e-154: 470: 11.38
+	Sc
		1084459 APC11_YEAST (1-82): 2.74e-30: 106: 40.00		APC2_YEAST (240-802): 7.94e-114: 367: 20.37
+	Sp
		152067 RBX1_SCHPO (2-82): 5.88e-28: 98.6: 38.37		CUL3_SCHPO (490-694): 3.51e-37: 151: 21.50