HitPredict

Interactor 1: KBTB6 (Q86V97)
Kelch repeat and BTB domain-containing protein 6
Gene: KBTBD6

Interactor 2: MLP3A (Q9H492)
Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A)
Gene: MAP1LC3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	25684205
Identification Methods	isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 674 Hs			1 121
+	Hs
		1358856 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		MLP3A_HUMAN (1-121): 4.21e-54: 167: 100.00
+	Hs
		952265 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		1358849 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		328087 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		GBRAP_HUMAN (7-121): 3.01e-52: 161: 30.44
+	Hs
		1358844 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		MLP3C_HUMAN (1-120): 5.65e-51: 159: 59.17
+	Hs
		1358852 KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05
+	Hs
		952228 KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		1290297 KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		328058 KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00		GBRAP_HUMAN (7-121): 3.01e-52: 161: 30.44
+	Hs
		1290293 KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00		MLP3C_HUMAN (1-120): 5.65e-51: 159: 59.17
+	Hs
		1290299 KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05
+	Dm
		1269043 Q7KSF5_DROME (435-673): 2.29e-48: 183: 13.93		Q9W2S2_DROME (3-121): 3.49e-53: 164: 30.25
+	Hs
		1121526 KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99		MLP3A_HUMAN (1-121): 4.21e-54: 167: 100.00
+	Hs
		952160 KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		1121519 KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		328002 KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99		GBRAP_HUMAN (7-121): 3.01e-52: 161: 30.44
+	Hs
		1121523 KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05
+	Hs
		952295 KLHL5_HUMAN (256-483): 9.34e-27: 118: 14.59		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		1399935 KLHL5_HUMAN (256-483): 9.34e-27: 118: 14.59		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		1199032 KLH12_HUMAN (505-673): 2.53e-25: 112: 13.37		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82