HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: KBTB6 (Q86V97)
Kelch repeat and BTB domain-containing protein 6
Gene: KBTBD6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.846

Property	Details
Experiments	25684205, 20562859
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 674
+	Hs
		952265 GBRL2_HUMAN (1-117): 1.09e-58: 178: 100.00		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		328087 GBRAP_HUMAN (1-117): 7.58e-57: 173: 57.27		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358852 GBRL1_HUMAN (1-116): 7.93e-56: 170: 61.21		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		328058 GBRAP_HUMAN (1-117): 7.58e-57: 173: 57.27		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290299 GBRL1_HUMAN (1-116): 7.93e-56: 170: 61.21		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1358844 MLP3C_HUMAN (5-116): 5.11e-45: 144: 42.11		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358856 MLP3A_HUMAN (5-117): 2.02e-45: 144: 41.74		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358849 MLP3B_HUMAN (2-117): 6.37e-44: 141: 38.14		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1290293 MLP3C_HUMAN (5-116): 5.11e-45: 144: 42.11		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290302 MLP3A_HUMAN (5-117): 2.02e-45: 144: 41.74		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290297 MLP3B_HUMAN (2-117): 6.37e-44: 141: 38.14		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Dm
		1269043 Q9W2S2_DROME (1-117): 5.37e-58: 176: 57.27		Q7KSF5_DROME (435-673): 2.29e-48: 183: 13.93
+	Hs
		952160 GBRL2_HUMAN (1-117): 1.09e-58: 178: 100.00		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		328002 GBRAP_HUMAN (1-117): 7.58e-57: 173: 57.27		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1121523 GBRL1_HUMAN (1-116): 7.93e-56: 170: 61.21		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		952295 GBRL2_HUMAN (1-117): 1.09e-58: 178: 100.00		KLHL5_HUMAN (256-483): 9.34e-27: 118: 14.59
+	Hs
		1121526 MLP3A_HUMAN (5-117): 2.02e-45: 144: 41.74		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1121519 MLP3B_HUMAN (2-117): 6.37e-44: 141: 38.14		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1199037 MLP3A_HUMAN (5-117): 2.02e-45: 144: 41.74		KLH12_HUMAN (505-673): 2.53e-25: 112: 13.37
+	Hs
		1199032 MLP3B_HUMAN (2-117): 6.37e-44: 141: 38.14		KLH12_HUMAN (505-673): 2.53e-25: 112: 13.37