HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: KBTB6 (Q86V97)
Kelch repeat and BTB domain-containing protein 6
Gene: KBTBD6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.859

Property	Details
Experiments	25684205, 20562859
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005829 - cytosol GO:0035020 - regulation of Rac protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 674
+	Hs
		952265 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		328087 GBRAP_HUMAN (1-117): 8.09e-57: 173: 100.00		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358852 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		952228 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290299 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1358856 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358844 MLP3C_HUMAN (5-116): 1.16e-44: 143: 38.60		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1358849 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KBTB7_HUMAN (1-674): 1.55e-165: 492: 89.76
+	Hs
		1290302 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290293 MLP3C_HUMAN (5-116): 1.16e-44: 143: 38.60		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Hs
		1290297 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KBTB6_HUMAN (1-674): 8.93e-160: 477: 100.00
+	Dm
		1269043 Q9W2S2_DROME (1-117): 5.31e-58: 176: 91.45		Q7KSF5_DROME (435-673): 2.29e-48: 183: 13.93
+	Hs
		952160 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		328002 GBRAP_HUMAN (1-117): 8.09e-57: 173: 100.00		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1121523 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		952295 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KLHL5_HUMAN (256-483): 9.34e-27: 118: 14.59
+	Hs
		1121526 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1121519 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KEAP1_HUMAN (471-673): 8.13e-37: 148: 13.99
+	Hs
		1199037 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KLH12_HUMAN (505-673): 2.53e-25: 112: 13.37
+	Hs
		1199032 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KLH12_HUMAN (505-673): 2.53e-25: 112: 13.37